CAS: 89889-52-1; 2,5-Dioxopyrrolidin-1-Yl 6-(6-(5-((3As,4S,6Ar)-2-Oxohexahydro-1H-Thieno[3,4-D]Imidazol-4-yl)Pentanamido)Hexanamido)Hexanoate

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CAS号58-85-5 D-生物素

专利信息

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-6288221-B1
优先权日:1998-08-20
标 题 :Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
发明人：GRINSTAFF MARK W; BEILSTEIN AMY E; KHAN SHOEB I
权利人:UNIV DUKE
摘要:The present invention provides metal-containing purines, pyrimidines, nucleosides, nucleotides and oligonucleotides; including phosphoramidite and photolabile derivatives thereof, including methods of making and method of using same. The present invention provides a method for detection of nucleic acid sequences via electrochemical or photochemical means.

专利号:WO-9203464-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule

专利号:JP-H06500556-A
优先权日:1990-08-28
标题 :Solid-support synthesis of 3'-tailed oligonucleotides via linking molecules

专利号:EP-0547142-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule

专利号:US-7122549-B2
优先权日:2000-11-03
标题:Saframycins, analogues and uses thereof
发明人：MYERS ANDREW G; PLOWRIGHT ALLEYN T
权利人:HARVARD COLLEGE
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. n n n n n n n n n n In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.