CAS: 83012-13-9; 4-Chloro-2,8-Bis-Trifluoromethylquinoline

相似化合物

1701-25-3 23779-97-7 1701-26-4

上下游产品

CAS号35853-41-9 2,8-双(三氟甲基)-4-羟基喹啉 | CAS号35853-55-5 双[2,8-二(三氟甲基)喹啉... | CAS号83012-12-8 alpha,2-pyridyl...

📜邻氨基三氟甲苯置于magnesium Sulfate,溶剂黄146,三氯化磷体系中,用 乙醇 作为反应溶剂,化学反应 19.5H,反应生成 4-氯-2,8-双(三氟甲基)喹啉
参考文献:天然奎宁生物碱启发的新型喹啉衍生物的设计,合成和抗真菌评价
标题:天然奎宁生物碱启发的新型喹啉衍生物的设计,合成和抗真菌评价
摘要:受奎宁及其类似物的启发,我们设计,合成和评估了两个系列的喹啉小分子化合物(a和2A)和六个系列的喹啉衍生物(3A-F)的抗真菌活性.结果表明,化合物3E和3F系列表现出显着的杀真菌活性.值得注意的是,化合物3F-4(ec 50 = 0.41μg/ Ml)和3F-28(ec 50 = 0.55μg/ Ml)显示出优异的体外杀真菌活性和对菌核菌的有效体内治疗作用.初步机理研究表明,化合物3F-4和3F-28可能引起细胞膜通透性改变,活性氧的积累,线粒体膜电位的丧失以及有效抑制菌核菌的发芽和形成.这些结果表明,化合物3F-4和3F-28是对抗源自天然产物的核盘菌的新型潜在杀真菌剂.
DOI:10.1021/acs.Jafc.9B04224

专利信息

专利号:US-6500955-B1
优先权日:2001-02-02
标 题:One pot synthesis of [2,8-Bis (trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, a mefloquine intermediate
发明人：CHAWLA HARMANDER PAL SINGH; JOHAR PERMINDER SINGH; MITTAL ALKA; MEENA RAM AVTAR; NEGI VILLENDRA SINGH
权利人:NAT INST OF PHARMACEUTICAL EDU
摘要:The present invention provides a simple single step process for the preparation of [2,8-bis(trifluoromethyl)-4-quinolinyl]-2-pyridinylmethanone, comprising the step of condensing a halo-quinoline with an alpha-picolyl derivatives in the presence of a solvent, a base and a phase transfer catalyst at −10° C. to +90° C.

专利号:US-2012122923-A1
优先权日:2006-06-13
标 题:Dual molecules containing a peroxide derivative, their synthesis and therapeutic uses
发明人：COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN
权利人:COSLEDAN FREDERIC; MEUNIER BERNARD; PELLET ALAIN; SANOFI AVENTIS; PALUMED SA; CENTRE NAT RECH SCIENT
摘要:The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R 5 represents a hydrogen atom, an alkyl, cycloalkyl or C 1-3 -alkylene-cycloakyl group; Z 1 and Z 2 represent an alkyl radical, the group Z 1 +Z 2 +C i +C j representing a mono- or polycyclic structure, with one of the Z 1 or Z 2 being able to represent a single bond; R 1 and R 2 , identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; R x and R y forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R 3 groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diasteroisomers and their mixtures. Preparation method and use as medications with antimalarial activity.

专利号:HU-P0401607-A2
优先权日:2004-08-10
标题 :Synthesis of aminoquinoline derivatives and of their starting materials

专利号:US-2002188129-A1
优先权日:2001-02-02
标题:One pot synthesis of [2, 8-bis (trifluoromethyl)-4- quinolinyl]2-pyridinylmethanone, a mefloquine intermediate

专利号:RU-2034842-C1
优先权日:1989-07-25
标题:Quinoline derivative and a method of its synthesis