CAS: 80-18-2; Methyl Benzenesulfonate

上下游产品

CAS号67-56-1 甲醇 | CAS号98-09-9 苯磺酰氯 | CAS号124-41-4 甲醇钠 | CAS号1825-61-2 甲氧基三甲基硅烷 | CAS号368-43-4 苯磺酰氟 | CAS号74-88-4 碘甲烷 | CAS号30863-82-2 2,4,6-tris(phen... | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号142-45-0 丁炔二酸 | CAS号934-55-4 potassium,benze... | CAS号515-42-4 苯磺酸钠 | CAS号74-87-3 氯甲烷 | CAS号74-83-9 溴甲烷 | CAS号14417-01-7 N,N-二甲基苯磺酰胺 | CAS号938-33-0 8-甲氧基喹啉 | CAS号115-10-6 二甲醚 | CAS号98-11-3 苯磺酸 | CAS号938-16-9 2-甲基丙酮 | CAS号14613-33-3 benzylamine, be...

苯磺酸置于tetrabutylammonium Tetrafluoroborate,三乙胺,N,N'-羰基二咪唑体系中,用 乙腈 作为反应溶剂,化学反应 16.5H,反应生成 苯磺酸甲酯
参考文献:磺酰肼电化学合成亚磺酸酯和磺酸酯
标题:磺酰肼电化学合成亚磺酸酯和磺酸酯
摘要:开发了一种由磺酰肼合成亚磺酸酯和磺酸酯的电化学合成方法.在dmf溶剂中,5 Ma恒电流下,用原甲酸三烷基酯处理磺酰肼,然后优化反应条件,合成烷基亚磺酸酯.相反,当反应在烷基醇溶剂中以15Ma的恒定电流进行时,仅获得烷基磺酸酯.各种取代的芳基磺酰肼提供了中等至非常好产率的所需亚磺酸酯和磺酸酯.机理研究表明,磺酰基自由基是通过电化学氧化形成的,并且它们与烷基自由基或烷氧基自由基反应反应生成各自的酯产物.
DOI:10.1039/d4Ob00215F

专利信息

专利号:US-8791287-B2
优先权日:2010-07-02
标 题:Process for the synthesis of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA; EUTICALS SPA
摘要:The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. n A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. n Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. n A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人：FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:US-8133707-B2
优先权日:2006-01-17
标 题 :Methods of preparing activated polymers having alpha nitrogen groups
发明人：ZHAO HONG; WU DECHUN
权利人:ZHAO HONG; WU DECHUN; ENZON PHARMACEUTICALS INC
摘要:Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

专利号:US-4697001-A
优先权日:1984-09-04
标题:Chemical synthesis of conducting polypyrrole
发明人：WALKER JOHN A; WITUCKI EDWARD F; WARREN LESLIE F
权利人:ROCKWELL INTERNATIONAL CORP
摘要:Production of electrically conductive polypyrrole of enhanced stability by treating a liquid pyrrole with a solution of a strong oxidant, capable of oxidizing pyrrole to a pyrrole polymer, and oxidizing the pyrrole by such strong oxidant in the presence of a relatively large organic dopant anion, and precipitating a conductive polypyrrole. The strong oxidant, e.g., Fe3+ ion, and dopant anion, which can be an alkyl or aryl sulfonate, e.g., methylbenzenesulfonate, or a perfluorinated carboxylate, e.g., trifluoroacetate, anion, can be derived from a single compound, e.g., the anion serving as dopant for the polypyrrole.