CAS: 7753-60-8; [2-[(8S,10S,13S,14S,17R)-17-Hydroxy-10,13-Dimethyl-3-Oxo-2,6,7,8,12,14,15,16-Octahydro-1H-Cyclopenta[a]Phenanthren-17-Yl]-2-Oxoethyl] Acetate

上下游产品

CAS号50-03-3 醋酸氢化可的松 | CAS号75868-48-3 21-chloro-17-hy... | CAS号63973-98-8 21-bromo-17-hyd... | CAS号3800-41-7 21-Acetoxy-9α-b... | CAS号108674-98-2 (8S,9R,10S,13S,... | CAS号113862-93-4 21-Acetoxy-17α-... | CAS号566-35-8 11-表氢化可的松 | CAS号428516-04-5 21-acetoxy-3,3,... | CAS号514-36-3 醋酸氟氢可的松 | CAS号2398-99-4 9-脱氢睾丸激素 | CAS号10184-70-0 21-脱乙酰草甘膦 | CAS号10072-97-6 (9β,11β)-环氧氢化可的松 | CAS号127-31-1 氟氢可的松

醋酸氢化可的松 以90的收率获得产物醋酸阿奈可他
参考文献:一种制备二氟泼尼酯的方法
标题:一种制备二氟泼尼酯的方法
摘要:本发明公开了二氟泼尼酯的一种新型制备方法.以市场上常见且价格低廉的氢化可的松-21-醋酸酯为原料,通过羟基消除成9,11位双键,17位丁酸酯化,6,9位氟代以及1,2位脱氢最终得到二氟泼尼酯,共九步反应.其中17位丁酸酯化可以一步定量得到关键中间体化合物iv,从而大大简化了原有工艺;两步氟代反应采用的试剂环保低毒,反应条件温和,适合工业化生产.该方法与文献报道方法相比,路线更短,操作更简便,收率和成本等方面都具有明显的优势.

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-5565588-A
优先权日:1986-10-10
标题:9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing said steroids
发明人：BATIST JACOBUS N M; MARX ARTHUR F; VAN ZOEST WILLEM J; KAPUR JAGDISH C
权利人:ROUSSEL UCLAF
摘要:New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. n The resulting compounds are useful intermediates in the synthesis of corticosteroids.

专利号:US-4041055-A
优先权日:1975-11-17
标题:Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
发明人：SHEPHARD KENNETH PAUL; VAN RHEENEN VERLAN H
权利人:UPJOHN CO
摘要:This invention discloses a general process for the production of corticoids from androstenes. This invention provides an economically viable alternative synthesis of 17α-hydroxyprogesterones and the corticoids.

专利号:US-9650407-B2
优先权日:2011-11-02
标 题 :Reprogramming of cellular adhesion
发明人：GARTNER ZEV JORDAN; SELDEN NICHOLAS SCOTT; TODHUNTER MICHAEL E; LIANG SAMANTHA ISABEL; WEBER ROBERT JOSEPH; JEE NOEL YOUNGHO; LIU JENNIFER S
权利人:UNIV CALIFORNIA
摘要:Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications.