专利号:US-8008504-B2 优先权日:2005-06-09 标题 :Process for the synthesis of organic compounds 发明人:ABEL STEPHAN; ACEMOGLU MURAT; ERB BERNHARD; KRELL CHRISTOPH; SCLAFANI JOSEPH; MEISENBACH MARK; PRASHAD MAHAVIR; SHIEH WEN-CHUNG; XUE SONG 权利人:NOVARTIS AG 摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):
专利号:US-12150934-B2 优先权日:2016-11-30 标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases 发明人:SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD 权利人:BANTAM PHARMACEUTICAL LLC 摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
专利号:US-2010280257-A1 优先权日:2005-06-09 标 题:Process for the synthesis of organic compounds
专利号:CN-112778125-A 优先权日:2021-02-01 标题:A kind of aryl phenolic compound and its synthesis method and application