CAS: 6480-68-8; Quinoline-3-Carboxylic Acid

该化合物是一种芳烃式的盒状碳酸,其特点是其quinoline结构,由一个有引信的苯乙烯和环组成,这种化合物一般在室温时是一种固体,由于存在箱状酸功能组,其酸性特性较弱,因此闻名为固体,在有机溶剂中可溶解,水溶性有限,该化合物对包括药用化学和有机合成在内的各个领域都感兴趣,因为它在药物开发中的潜在生物活动和用途.此外,3-quinocarboxylic酸可以作为合成更复杂分子的建筑块,其衍生物可能具有多种药用特性,成为药物发现研究的课题.安全数据表明,与许多有机化合物一样,应谨慎处理,因为如果摄入或吸入,可能会对健康造成危害.

结构式图片

相似化合物

13669-42-6 34846-64-5 53951-84-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号612-58-8 3-甲基喹啉 | CAS号5332-24-1 3-溴喹啉 | CAS号201230-82-2 carbon monoxide | CAS号17609-48-2 D-苯甘氨酸乙酯盐酸盐 | CAS号120277-70-5 3-溴甲基喹啉 | CAS号34846-64-5 3-氰基喹啉 | CAS号13669-42-6 3-喹啉甲醛 | CAS号124-38-9 二氧化碳 | CAS号590-29-4 甲酸钾 | CAS号33021-53-3 3-乙酰基喹啉 | CAS号50741-46-3 3-喹啉甲酸乙酯 | CAS号491-34-9 1-甲基-1,2,3,4-四氢喹啉 | CAS号53951-84-1 3-喹啉甲酸甲酯 | CAS号13669-51-7 喹啉-3-基甲醇 | CAS号114527-53-6 1,2,3,4-四氢喹啉-3-甲酸 | CAS号13669-42-6 3-喹啉甲醛 | CAS号6480-67-7 quinoline-3-car... | CAS号753487-72-8 methyl 2,4-dicy... | CAS号67752-37-8 1,2,3,4-四氢喹啉-3-羧酸乙酯 | CAS号84741-86-6 3-喹啉羰酰氯

合成工艺路线路线简述

    3-乙基喹啉置于硫酸,铬酸体系中,化学反应生成 喹啉-3-羧酸
    参考文献:Riedel,Chemische Berichte,1883,Vol. 16,P. 1613
    标题:Riedel,Chemische Berichte,1883,Vol. 16,P. 1613

    海关参考信息

    专利信息


    专利号:US-6815214-B2
    优先权日:2000-12-29
    标 题 :Pharmaceutical uses and synthesis of diketopiperazines
    发明人:BOYCE JIM P; HOWBERT J JEFFRY; TABONE JOHN C
    权利人:CELLTECH R & D INC
    摘要:The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of diverse diketopiperazines and process for their synthesis as a library and as individual compounds. In particular novel diketopiperazines are disclosed including their synthesis and use in cellular events such as activation of the transcription factor, nuclear factor, TNF-α, TNF-β and also apoptosis.

    专利号:US-9630923-B2
    优先权日:2013-07-09
    标题:Biocatalyzed synthesis of the optically pure (R) and (S) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21R)- and (21S)-argatroban
    发明人:GRISENTI PARIDE
    权利人:EUTICALS SPA; EUTICALS SPA
    摘要:The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3R) and (3S)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21R) and (21S)-agratroban and its analogs. New compounds used as intermediates in the process of the invention are also disclosed.

    专利号:WO-9611194-A1
    优先权日:1994-10-06
    标题:Pyridonecarboxylic acid derivative and intermediate for the synthesis of the same
    发明人:OKADA HIDETSUGU; CHIBA KATSUMI; TOMINAGA YUKIO; MINAMI AKIRA
    权利人:DAINIPPON PHARMACEUTICAL CO; OKADA HIDETSUGU; CHIBA KATSUMI; TOMINAGA YUKIO; MINAMI AKIRA
    摘要:A pyridonecarboxylic acid derivative represented by general formula (I), an ester and a salt thereof, an antibacterial agent containing the same, and a bicyclic amine compound serving as a direct intermediate for the synthesis of the pyridonecarboxylic acid derivative, wherein R represents cycloalkyl, optionally substituted phenyl, etc.; G represents carbon, etc.; A represents C-Z (Z being hydrogen, halogeno, lower alkoxy, etc.) or nitrogen; X represents hydrogen, amino, etc.; Y represents hydrogen or halogeno; m is an integer of 1 to 3; and W represents -(CH2)nN(R1)R2 (R1 and R2 being the same or different and each representing hydrogen, lower alkyl, etc., and n being an integer of 0 or 1).

    专利号:US-2013261317-A1
    优先权日:2010-09-27
    标题 :Methods for preparing synthetic bile acids and compositions comprising the same
    发明人:MORIARTY ROBERT M; RAO PHOTON
    权利人:MORIARTY ROBERT M; RAO PHOTON; KYTHERA BIOPHARMACEUTICALS INC
    摘要:This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C 14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.

    专利号:US-2009215080-A1
    优先权日:2005-10-13
    标题:Methods for identification of inhibitors of enzyme activity
    发明人:SINHA SUKANTO; CHILCOTE TAMIE JO
    权利人:ACTIVESITE PHARMACEUTICALS
    摘要:The invention discloses compositions and methods of synthesis to create novel ligands and drugs and identifying such compounds as inhibitors of enzyme targets for use in the treatment of clinical disorders, including cancer, infectious diseases, parasitic infestations, neurological disorders, reproductive disorders, inflammatory disorders, circulatory disorders, and metabolic disorders.

    专利号:US-2005080086-A1
    优先权日:2000-12-29
    标 题 :Pharmaceutical uses and synthesis of diketopiperazines
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    主要参考文献

    [参考文献]: Antonello Mai, Et Al. Small-Molecule Inhibitors Of Histone Acetyltransferase Activity: Identification And Biological Properties. J Med Chem. 2006 Nov 16;49(23):6897-907.
    [参考文献]: Ximei Liang, Et Al. Effects Of Norfloxacin On Hepatic Genes Expression Of P450 Isoforms (Cyp1A And Cyp3A), Gst And P-Glycoprotein (P-Gp) In Swordtail Fish (Xiphophorus Helleri). Ecotoxicology. 2015 Oct;24(7-8):1566-73.

    合成参考文献


    参考文献:10.1007/s00253-001-0928-x
    摘要:Schräder T, Thiemer B, Andreesen JR. A molybdenum-containing dehydrogenase catalyzing an unusual 2-hydroxylation of nicotinic acid. Appl Microbiol Biotechnol. 2002 Apr;58(5):612–7. doi: 10.1007/s00253-001-0928-x.
    参考文献:10.1107/s1600536810039401
    摘要:Miao DL, Li SJ, Song WD, Liu JH, Li XF. catena-Poly[[diaqua-calcium(II)]-bis-(μ-quinoline-3-carboxyl-ato)]. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 23;66(Pt 11):m1441–2.
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