CAS: 6443-72-7; 3-(3,4-Dimethoxyphenyl)Acrylonitrile

上下游产品

CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号372-09-8 氰基乙酸 | CAS号16640-68-9 (三苯基膦)乙腈 | CAS号14773-42-3 3-(3,4-二甲氧基-苯基)-丙胺 | CAS号3988-51-0 安纽洛灵

📜异丁香酚甲醚置于叠氮基三甲基硅烷,氯化锆(Iv),2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 二氯甲烷,水,乙腈 作为反应溶剂,化学反应 4.0H,反应生成 3,4-二甲氧基肉桂酸
参考文献:从 C-木质素衍生的丙烯基儿茶酚可持续生产生物活性分子
标题:从 C-木质素衍生的丙烯基儿茶酚可持续生产生物活性分子
摘要:丢弃到生物活性分子:丙烯基儿茶酚是天然存在的儿茶基木质素的直接解聚产物,其多样化的功能化产生了一系列功能性分子骨架.从蓖麻种皮开始,以比报道的合成路线更高的步骤效率合成了annuloline(天然产物)和cc-5079 (抗肿瘤).
DOI:10.1002/cssc.202200646

专利信息

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779121-B2
优先权日:2012-10-12
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-9353112-B2
优先权日:2012-03-07
标 题 :Synthesis of polycyclic alkaloids
发明人：GOFF DANE; PAYAN DONALD G; BRASELMANN SYLVIA
权利人:RIGEL PHARMACEUTICALS INC
摘要:Disclosed embodiments concern polycyclic alkaloid compounds and methods for their use and synthesis. Particular embodiments concern polycyclic alkaloids having a fused, six-membered ring, while other embodiments concern polycyclic alkaloids having a fused, five-membered ring. Methods for making the polycyclic alkaloids are disclosed, as well as methods for their use as prophylactics or treatments for certain diseases. Also disclosed are pharmaceutical compositions comprising the polycyclic alkaloids and their use.

专利号:US-7034163-B2
优先权日:2003-09-05
标 题 :Synthesis of pyrroles
发明人：PAGENKOPF BRIAN L; YU MING
权利人:UNIV TEXAS
摘要:An improved and highly efficient method for the preparation of 2-R(R=alkyl, aryl, H) pyrroles from nitrites (RCN, R=alkyl, aryl) is described using Lewis acid activated donor-acceptor cyclopropanes to react with aliphatic, aromatic, branched, α,β-unsaturated, or otherwise functionalized nitrites in a cascade [3+2] dipolar cycloaddition, dehydration and tautomerization sequence.

专利号:US-2014128598-A1
优先权日:2012-11-08
标 题 :Process for the synthesis of (2e)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

专利号:US-2014107334-A1
优先权日:2012-10-12
标 题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid