CAS: 63775-96-2; Cyclosporin D

专利信息

专利号:US-4396542-A
优先权日:1980-02-14
标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人：WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-2006014987-A1
优先权日:2003-07-07
标 题:Synthesis of beta-elemene, intermediates thereto, analogues and uses thereof
发明人：HUANG LAN
权利人:HUANG LAN
摘要:The present invention provides convergent processes for preparing beta-elemene, and analogues thereof. Also provided are analogues related to beta-elemene and intermediates useful for preparing the same. The present invention further provides novel compositions based on analogues of beta-elemene and methods for the treatment of cancer, such as brain tumor, lung cancer, colorectal cancer, gastric intestional cancer, and stomach cancer.

专利号:US-5214130-A
优先权日:1990-02-27
标题 :Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8
发明人：PATCHETT ARTHUR A; TAUB DAVID; GOEGELMAN ROBERT T
权利人:MERCK & CO INC
摘要:New immunosuppressive cyclosporin analogs are disclosed consisting of [dehydro-Ala]8 cyclosporins and derived therefrom cyclosporins having a sulfur containing amino acid at position-8.

专利号:US-12201669-B2
优先权日:2021-03-11
标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology
发明人：TSAI LI-HUEI; BLANCHARD JOEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.

专利号:US-2007135526-A1
优先权日:2004-07-07
标 题 :Synthesis of (1)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and their analogues, intermediates, and composition and uses thereof

专利号:JP-2008505893-A
优先权日:2004-07-07
标题:Synthesis of Minus Beta Element, Minus Beta Elemental, Minus Beta Elementenol, Minus Beta Fluorinated Elementene and Their Analogues, Intermediates and Drugs