CAS: 63261-45-0; (1S,2S)-Cyclopentane-1,2-Diol

该化合物是一种阳性二醇,其特点是环球中脊柱的精密配置,该化合物是有机合成,特别是用于不对称反应和立体化学定义中间体的制作的宝贵构件,其硬性循环结构和氢氧化物组能够有效地衍生,使其在制药和农用化学应用中有用.1S 2S) 对应物提供了高抗性,确保对催化工艺中的立体化学结果的精确控制.普通有机溶剂的稳定性和溶解性进一步提高了其在复杂的合成途径中的效用.该二醇还被用于其立体化学特性影响的立体化学设计和聚合化学.

结构式图片

相似化合物

5057-98-7 5057-99-8 4065-92-3

物理性质

MSDS等安全信息

上下游产品

CAS号113350-83-7 (1S,2S)-(+)-1,2... | CAS号285-67-6 氧化环戊烯 | CAS号5057-99-8 (+/-)-反式-1,2-环戊二醇 | CAS号108-24-7 乙酸酐 | CAS号64-19-7 冰醋酸 | CAS号142-29-0 环戊烯 | CAS号128994-14-9 6,10-Dioxaspiro... | CAS号26620-22-4 1,2-Cyclopentan...

合成工艺路线路线简述

    📜(+/-)-反-1,2-环戊二醇 反应生成 (1S)-反-1,2-环戊二醇
    参考文献:Godchot; Mousseron; Richaud,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1934,Vol. 199,P. 1233
    标题:Godchot; Mousseron; Richaud,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1934,Vol. 199,P. 1233

    海关参考信息

    专利信息


    专利号:US-9862745-B2
    优先权日:2004-03-30
    标题 :Synthesis of boronic ester and acid compounds
    发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
    权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
    摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

    专利号:US-8115002-B2
    优先权日:2006-09-20
    标 题:Preparation of substituted morphinan-6-ones and salts and intermediates thereof
    发明人：WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W
    权利人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W; MALLINCKRODT LLC
    摘要:The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.

    专利号:US-8022235-B2
    优先权日:2007-06-01
    标 题 :Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
    发明人：PINCHUK ANATOLY; WEICHERT JAMEY P; LONGINO MARC
    权利人:CELLECTAR INC
    摘要:The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.

    专利号:US-2018265546-A1
    优先权日:2004-03-30
    标题 :Synthesis of boronic ester and acid compounds

    专利号:US-2005240047-A1
    优先权日:2004-03-30
    标 题:Synthesis of boronic ester and acid compounds

    专利号:US-2020157143-A1
    优先权日:2004-03-30
    标题 :Synthesis of boronic ester and acid compounds

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    主要参考文献

    参考标题:Chiral Synthesis Via Organoboranes. 45. Asymmetric Hydroboration Of 1-Cyclopentenol Derivatives Using Diisopinocampheylborane. Synthesis Of Optically Active Cyclopentane-1,2-Diol Derivatives Of High Optical Purity
    作者:Herbert C. Brown,Dhanabalan Murali,Bakthan Singaram |发布日期:1999.6
    摘要:The Asymmetric Hydroboration Of 1-Cyclopentenol Derivatives, Such As Ethers, Acetate, Silyl Ether And Borinate, Was Investigated Using Diisopinocampheylborane, Dipc2Bh. The Product Trialkylboranes Were Treated With Excess Of Acetaldehyde To Give The Corresponding Diethyl Boronate Esters. These Boronate Esters On Oxidation Using Alkaline Hydrogen Peroxide Gave Optically Active Trans-Cyclopentane-1,2-Diol

    合成参考文献


    摘要:Wohlgemuth, R., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 550.
    摘要:Stoltz, B. M.; Wright, A. C.; Ebner, D. C.; Park, N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 582.
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