CAS: 6310-19-6; 4-(Tert-Butyl)-2-Nitroaniline

上下游产品

4-tert-butylacetanilide N-(4-(tert-butyl)-2-nitrophenyl)acetamide tert-butylbenzene 4-tert-butylnitrobenzene 5-(1,1-dimethylethyl)-1,3-dihydrobenzimidazol-2-one 4-tert-butyl-2-nitrophenol 1-tert-butyl-3-nitrobenzene 1-Bromo-4-tert-butyl-2-nitro-benzene

📜N-乙酰苯胺置于甲醇,Aluminum (Iii) Chloride,Sodium Methylate,乙酸酐,溶剂黄146体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 5.42H,反应生成 4-(叔丁基)-2-硝基苯胺
参考文献: Benziimidazole And Imidazopyridine Derivatives As Sodium Channel Modulators[fr] Dérivés D'Imidazopyridine Et De Benziimidazole En Tant Que Modulateurs Du Canal Sodium
标题: Benziimidazole And Imidazopyridine Derivatives As Sodium Channel Modulators[fr] Dérivés D'Imidazopyridine Et De Benziimidazole En Tant Que Modulateurs Du Canal Sodium
摘要:这项发明涉及苯并咪唑和咪唑吡啶衍生物,它们在药物中的应用,含有它们的组合物,它们的制备方法以及用于这些方法的中间体.更具体地,该发明涉及公式(I)的新nav1.8调节剂或其药用盐,其中r1,R2,R3,R4,R5,R6,R7,X和y如描述中所定义.nav1.8调节剂在治疗各种疾病,特别是疼痛方面,具有潜在的用途.

专利信息

专利号:US-9738679-B2
优先权日:2013-03-15
标 题:Methods of synthesizing substituted purine compounds
发明人：OLHAVA EDWARD JAMES
权利人:EPIZYME INC
摘要:The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof and methods for treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also provides novel crystalline forms of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol and hydrates thereof (Form A, Form B, and Form C), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.