CAS: 595-15-3; Soyasapogenol B

该化合物是主要通过大豆水解而获得的大豆类三叶虫沙质素,其特征是其油气类骨骼,具有显著的生物特性,包括抗炎,肝脏保护和抗氧化剂等.Soyasapogenol B作为大豆类生物合成的关键中间体,由于它潜在的治疗用途,它对药物和营养素研究很感兴趣.它的结构稳定性和与各种有机溶剂的兼容性使其适合分析和合成化学研究.该化合物通常作为高纯度的粉末供应,确保研究和工业用途的可靠性.其有据可查的药性肿瘤特征进一步证明了其在药物开发和实用食品配方中的效用.

结构式图片

上下游产品

2)-β-D-xylopyranosyl(1->2)-6-O-methyl-β-D-glucuronopyranosyl-soyasapogenol B 22-O-β-D-glucopyranoside3-O-α-L-rhamnopyranosyl(1-2)-β-D-xylopyranosyl(1-2)-6-O-methyl-β-D-glucuronopyranosyl-soyasapogenol B 22-O-β-D-glucopyranoside soyasaponin I Cloversaponin IV methyl ester prosapogenol(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-4,6a,6b,8a,11,11,14b-Heptamethyl-4-trityloxymethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picene-3,9-diol 3,24-O-benzylidene soyasapogenol B melilotigenin C N-n-butyl-3β,22β-dibenzyloxyolean-12-ene-24-amide

合成工艺路线路线简述

    📜去氢大豆皂甙i置于盐酸,Sodium Tetrahydroborate体系中,用 甲醇,氯仿 作为反应溶剂,化学反应 2.25H,反应生成 大豆甾醇 B
    参考文献:满天金(desmodium Styracifolium)成分的研究.
    标题:满天金(desmodium Styracifolium)成分的研究.
    摘要:从desmodii Herba [满地香(desmodium Styracifolium(osbeck)merr)干燥的整株植物中分离出了两个三萜皂苷(1和2).(豆科)]及其化学结构被表征为大豆皂苷i和新的皂苷3-O-[α-L-鼠李糖基-(1----2)-β-D-吡喃半乳糖基-(1----2)通过化学和光谱方法分别测定β-D-D-葡萄糖醛酸吡喃糖基]大豆皂酚e.
    DOI:10.1248/cpb.37.2229

    海关参考信息

    专利信息


    专利号:US-11224566-B2
    优先权日:2016-12-29
    标题 :Composition comprising a crosslinked hyaluronic acid (HA) in combination with a low-molecular HA and/or an agent stimulating endogenous HA synthesis
    发明人:MALLARD CLAIRE; RIVAL YVES
    权利人:Galderma Holding SA
    摘要:A composition comprising, in a physiologically acceptable medium, a crosslinked hyaluronic acid (HA), having a degree of modification less than 1.9 mole %; a HA with a molecular weight of about 50 kDa or less; and/or an agent stimulating endogenous HA synthesis. Also disclosed is a cosmetic use of such composition in skin care and/or anti-ageing treatment.

    专利号:US-8257754-B2
    优先权日:2002-10-21
    标 题:Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE M; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-8486457-B2
    优先权日:2002-10-21
    标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-8557306-B2
    优先权日:2001-06-20
    标 题 :Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE; METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    专利号:US-6641848-B1
    优先权日:1998-05-29
    标题:Saponin or sapogenol compositions for increasing collagen IV synthesis
    发明人:BONTE FREDERIC; DUMAS MARC; PERRIER PIERRE
    权利人:DIOR CHRISTIAN PARFUMS
    摘要:The present invention relates in general terms to the use of saponins or sapogenols, particularly those extracted from a plant, preferably from soya or Medicago, in cosmetology and for the manufacture of pharmaceutical compositions for treating the skin in order to increase the amount of collagen IV in the dermo-epidermal junction. It further relates to novel cosmetic or pharmaceutical compositions which promote an increase in the amount of collagen IV in the dermo-epidermal junction, and to a method of cosmetic treatment using a saponin or a sapogenol. The invention is applicable in cosmetics, preferably in an anti-wrinkle treatment, and in pharmacy in the treatment of diseases associated with a deficiency of the dermo-epidermal junction resulting from an insufficient amount of collagen IV.

    专利号:US-7431948-B2
    优先权日:2001-06-20
    标 题:Compositions that treat or inhibit pathological conditions associated with inflammatory response
    发明人:TRIPP MATTHEW L; BABISH JOHN G; BLAND JEFFREY S; DARLAND GARY K; LERMAN ROBERT; LUKACZER DANIEL O; LISKA DEANN J; HOWELL TERRENCE
    权利人:METAPROTEOMICS LLC
    摘要:A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/jf0731550
    摘要:Zhang W, Popovich DG. Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis. J Agric Food Chem. 2008 Apr 23;56(8):2603–8. doi: 10.1021/jf0731550.
    参考文献:10.1271/bbb.69.2178
    摘要:WATANABE M, SUMIDA N, YANAI K, MURAKAMI T. Cloning and Characterization of Saponin Hydrolases fromAspergillus oryzaeandEupenicillium brefeldianum. Bioscience, Biotechnology, and Biochemistry. 2005 Jan;69(11):2178–85. doi: 10.1271/bbb.69.2178.
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