CAS: 5297-05-2; Digoxigenin Bisdigitoxide
该化合物是来自Digitalis植物的心脏球体,通常以其用于治疗心脏状况而闻名;该化合物具有一种具有多种糖糖糖的类固核,具体地说有两个数字氧素单位,可提高其溶性与生物活性;典型地,二氧基丁基双氧酚对纳+/K+ ATPase酶酶酶具有很强的亲近性,导致细胞内钙含量提高,心脏萎缩性改善;通常用于生物化学应用,特别是分子生物学作为标签剂,因为它能够与特定的抗体结合;该化合物在生理条件下相对稳定,但可能对水解具有敏感性,这可能会影响其生物活动;其药理效应取决于剂量,因此必须密切监测其使用,以避免毒性.
- 英文名称Digoxigenin Bisdigitoxide
- 中文名称地高辛配基二(洋地黄毒糖甙)
- IUPAC名称4-((3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one
- 其它别名digoxigenin-bis(digitoxoside); 12β,14β-Dihydroxy-5β-carda-20(22)-enolide-3β-yl 4-O-(2,6-dideoxy-β-D-altropyranosyl)-2,6-dideoxy-β-D-altropyranoside; 3β-[[2,6-Dideoxy-4-O-(2,6-dideoxy-β-D-ribo-hexopyranosyl)-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β,14β-card-20(22)-enolide; 3β-[[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide; (3beta,5beta,12beta)-3-((2,6-Dideoxy-4-o-(2,6-dideoxy-beta-D-ribo-hexopyranosyl)-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxycard-20(22)-enolide; 3beta-((2,6-Dideoxy-4-o-(2,6-dideoxy-beta-D -ribo-hexopyranosyl)-beta-D -ribo-hexopyranosyl)oxy)-12beta,14-dihydroxy-5beta-card-20(22)-enolide
- CAS编号5297-05-2
- MFCD编号:MFCD00236730
- EINECS号:226-143-0
- FDA UNII编号:PPY8HS8NF3
- 分子式:C35H54O11分子量:650.81
- 产品CID: 2297152
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
上下游产品
digoxin Digoxin dialdehydeDigoxigenin mono-digitoside合成工艺路线路线简述
📜地高辛置于sodium Periodate,6-氨基己酸体系中,用 甲醇 作为反应溶剂,化学反应 12.0H,反应生成 地高辛配基二(洋地黄毒糖甙)
参考文献:Regioselective Schiff'S Base Mediated Deglycosidation Of Digitalis Glycosides. New Efficient Synthesis Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside
标题:Regioselective Schiff'S Base Mediated Deglycosidation Of Digitalis Glycosides. New Efficient Synthesis Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside
摘要:Dialdehydes Derived From Digoxin Glycosides Via Sodium Periodate Oxidation Were Regioselectively Deglycosylated By Various Amino Acids In Anhydrous Methanolic Solution To Afford Excellent Yields Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside In A Single Step.
DOI:10.1016/0040-4039(94)02212-T
参考文献:Regioselective Schiff'S Base Mediated Deglycosidation Of Digitalis Glycosides. New Efficient Synthesis Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside
标题:Regioselective Schiff'S Base Mediated Deglycosidation Of Digitalis Glycosides. New Efficient Synthesis Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside
摘要:Dialdehydes Derived From Digoxin Glycosides Via Sodium Periodate Oxidation Were Regioselectively Deglycosylated By Various Amino Acids In Anhydrous Methanolic Solution To Afford Excellent Yields Of Digoxigenin Bis-Digitoxoside And Digoxigenin Mono-Digitoxoside In A Single Step.
DOI:10.1016/0040-4039(94)02212-T
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CA-2849923-A1
优先权日:2011-10-12
标 题:Synthesis of mse-framework type molecular sieves
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Wu W, Gong P, Li J, Yang J, Zhang G, Li H, Yang Z, Zhang X. Simple and nonradioactive detection of microRNAs using digoxigenin (DIG)-labeled probes with high sensitivity. RNA. 2014 Apr;20(4):580-4. doi: 10.1261/rna.042150.113. Epub 2014 Feb 26.
2: Tokunaga S, Stegeman JJ. Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system. Anal Biochem. 2014 Nov 15;465:70-2. doi: 10.1016/j.ab.2014.06.020. Epub 2014 Jul 5.
3: Deng Z, Su S, Meng X, Wu Y, Yang R, Han Y. [Detection of Yersinia pestis sRNA by digoxigenin-labeled Northern blot]. Wei Sheng Wu Xue Bao. 2013 Mar 4;53(3):293-8. Chinese. doi: 10.2144/000114427. eCollection 2016. doi: 10.1111/j.1755-5922.2010.00242.x. Epub 2010 Oct 20. Review. doi: 10.1016/j.aca.2009.05.023. Epub 2009 May 21. doi: 10.1101/pdb.prot5655. doi: 10.1002/cbdv.201500024.
合成参考文献
参考文献:10.1016/j.antiviral.2011.06.015
摘要:Bertol JW, Rigotto C, de Pádua RM, Kreis W, Barardi CR, Braga FC, Simões CM. Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata. Antiviral Res. 2011 Oct;92(1):73–80. doi: 10.1016/j.antiviral.2011.06.015.
📝 需求与反馈
尽可能描述清楚需求与问题信息
