CAS: 454-81-9; 2-Amino-4-(Trifluoromethyl)Phenol

上下游产品

CAS号400-99-7 4-羟基-3-硝基三氟甲苯 | CAS号7772-99-8 无水氯化亚锡 | CAS号402-45-9 4-(三氟甲基)苯酚 | CAS号121-17-5 4-氯-3-硝基三氟甲苯 | CAS号400-98-6 2-硝基-4-三氟甲基苯胺 | CAS号35852-58-5 3-氯-4-羟基三氟甲苯 | CAS号14733-68-7 5-(三氟甲基)苯并[d]恶唑... | CAS号19420-46-3 [2-hydroxy-5-(t... | CAS号13451-80-4 5-(Trifluoromet... | CAS号114997-91-0 2-氯-5-(三氟甲基)苯并[d]噁唑 | CAS号68281-49-2 ethyl 6-(triflu... | CAS号921198-83-6 N-[2-hydroxy-5-...

📜对三氟甲基苯酚置于硝酸,铁粉,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 1.75H,反应生成 2-氨基-4-三氟甲基苯酚
参考文献:新型2-甲氧基-2'-羟基苯甲腈,它们的硫代类似物和苯并恶唑的合成及其体外抗分枝杆菌和异柠檬酸裂合酶抑制特性
标题:新型2-甲氧基-2'-羟基苯甲腈,它们的硫代类似物和苯并恶唑的合成及其体外抗分枝杆菌和异柠檬酸裂合酶抑制特性
摘要:合成了一系列新的2-甲氧基-2'-羟基苯甲腈衍生物及其硫代类似物,并通过红外,核磁共振和元素分析对其进行了表征.这些化合物进行了调查其体外抗分支杆菌活性针对结核分枝杆菌331 / 88,鸟分枝杆菌330 / 88,堪萨斯分枝杆菌235 / 80,临床分离堪萨斯分枝6509 / 96和充当能力体外异柠檬酸裂解酶抑制剂.最好的icl抑制剂是硫代苯甲腈类的两种化合物(8F,8M),其显示出与标准化合物3-硝基丙酸相同的抑制潜能.另外,具有5-Cl和4'或5'Cl / Br取代的苯甲酰苯胺衍生物6H,6K和6L表现出最佳的抗分枝杆菌性能.对于所有测试的硫代苯甲腈衍生物,在NMR谱图中观测到两个构象异构体,这很可能是由于c-n键的旋转受阻所致.
DOI:10.1016/j.Ejmech.2012.08.016

专利信息

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-2003009034-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:US-2003109714-A1
优先权日:2001-03-22
标题 :Transition metal mediated process
发明人：WISHART NEIL; RUDOLPH ALENA; RITTER KURT
摘要:This invention relates to a transition metal mediated process for the preparation of optionally substituted 2-amino-benzoxazoles and or 2-amino-benzimidazoles, which are useful as therapeutic agents or as intermediates in the synthesis of therapeutic agents.

专利号:CN-119241459-A
优先权日:2024-09-03
标题:Benzo (A) benzo (B) benzo (A oxazole/benzo Synthesis method of thiazole compound