CAS: 4352-30-1; Cyclohexylmethanesulfonyl Chloride

相似化合物

4837-38-1 4352-59-4 919354-63-5

上下游产品

thiourea Cyclohexylmethyl bromide cyclohexylmethyl chloride S-(cyclohexylmethyl) ethanethioateC-cyclohexyl-N-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}methanesulfonamide 1-(1-cyclohexylmethanesulfonyl-piperidin-4-ylmethyl)-4-(3-nitrophenyl)piperazine N-{4-[4-(3-aminophenyl)piperazin-1-yl]butyl}-C-cyclohexyl-N-methylmethanesulfonamide C-cyclohexyl-N-methyl-N-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}methanesulfonamide

📜环己基甲硫醇乙酸置于n-氯代丁二酰亚胺体系中,化学反应生成 环己基甲烷磺酰氯
参考文献:Inhibitors Of The Myst Family Of Lysine Acetyl Transferases
标题:Inhibitors Of The Myst Family Of Lysine Acetyl Transferases
摘要:本文提供的是式 (I) 化合物.本文描述了制备式(i)化合物的方法以及用于制备式(i)化合物的中间体.式(i)化合物可作为赖氨酸乙酰转移酶(kats)myst 家族的抑制剂,用于治疗和/或预防过度增殖性疾病,紊乱或癌症等病症.特别是,式(i)化合物可用于抑制 Kat6A 和 Kat6B,这两种酶在癌症中经常发生突变,过表达,扩增和/或易位,从而改变了它们的正常表达,活性和功能.进一步描述了式(i)化合物在制造药物组合物或治疗癌症中的用途,包括与其他抗癌剂联合治疗癌症.

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:RU-2184110-C2
优先权日:1996-12-23
标 题 :Derivatives of nitromethylthiobenzene, method of their synthesis (versions) and pharmaceutical composition

专利号:US-7491727-B2
优先权日:2003-01-31
标题:Arylpiperazinyl compounds
发明人：DHANOA DALE S; CHEN DONGLI; BECKER OREN; NOIMAN SILVIA; CHERUKU SRINIVASA R; MARANTZ YAEL; SHARADENDU ANURAG; SHACHAM SHARON; HEIFETZ ALEXANDER; MOHANTY PRADYUMNA; INBAL BOAZ; FICHMAN MERAV; NUDELMAN RAPHAEL; BAR-HAIM SHAY
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.