CAS: 4214-76-0; 2-Amino-5-Nitropyridine

相似化合物

161117-88-0 4318-76-7 6343-98-2

上下游产品

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2-氨基吡啶置于硫酸,硝酸体系中,化学反应生成 2-氨基-5-硝基吡啶
参考文献:一种合成2-羟基-5-硝基吡啶的一锅法合成方法
标题:一种合成2-羟基-5-硝基吡啶的一锅法合成方法
摘要:本发明公开了一种合成2‑羟基‑5‑硝基吡啶的一锅法合成方法,具体反应步骤如下:分批将2‑氨基吡啶加入浓硫酸中,控温10~20oc加入浓硝酸,完后保温40~50oc搅拌;硝化完成后,将反应液加入水中淬灭,控温0~10oc滴加亚硝酸钠水溶液,进行重氮反应;加入适量氨水调节酸的浓度;对酸浓度调节完成后的溶液进行过滤,滤饼烘干即得产品.本发明提供了一种新的2‑羟基‑5‑硝基吡啶制备方法,具有后处理简单,利用酸的浓度分离异构体,不需单独纯化硝化反应产生的异构体;硝化反应和重氮化反应连续操作,从而大大减少放大生产中产生的废水,节约生产成本等优点;本发明从未有文献报道,是一种全新的2‑羟基‑5‑硝基吡啶制备方法,并为其类似化合物提供了一种新的合成思路.

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-5144038-A
优先权日:1990-07-17
标题:Process for the production of 2-hydroxy-3-halo-5-nitropyridines
发明人：WORSCH DETLEV
权利人:LONZA AG
摘要:A process for the production of 2-hydroxy-3-halo-5-nitropyridines, in which a 5-halo-6-hydroxynicotinic acid is nitrated in the end product. The resultant pyridines form valuable intermediate products for active ingredient synthesis.

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:CN-112745259-A
优先权日:2021-02-04
标题:A kind of one-pot synthesis method of synthesizing 2-hydroxy-5-nitropyridine