专利号:US-7662401-B2 优先权日:2002-04-08 标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase 发明人:MAHE YANN; MEYBECK ALAIN 权利人:OREAL 摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.
专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-7128914-B2 优先权日:2001-11-14 标 题 :Product containing an extract of red algae of the genus Porphyra and methods for protecting cells 发明人:LECLERC CHRISTIAN; PAUL FRANCOIS 权利人:LARENA 摘要:A composition that induces synthesis of stress protective proteins during application of physical or physiological stresses, or physiopathological aggressions on cells including a water-alcohol extract of red algae, taurine and derivatives: about 1 to about 5%, floridoside and derivatives: about 10 to about 25%, one or more of carotenoids and PUFAs, one or more water-soluble vitamins, one or more free amino acids and derivatives, and one or more pigments; and a method of protecting skin against wrinkle formation including administering a therapeutically effective amount of a composition including a water-alcohol extract of red algae that induces synthesis of stress protective proteins during physical or physiological stresses, or physiopathological aggressions on skin cells.
专利号:US-9757317-B2 优先权日:2014-09-12 标题 :Cosmetic compositions and methods for inhibiting melanin synthesis 发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR 权利人:PROCTER & GAMBLE 摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
专利号:US-9498420-B2 优先权日:2013-05-01 标 题:Cosmetic compositions and methods for inhibiting melanin synthesis 发明人:LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI 权利人:PROCTER & GAMBLE 摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
1: Beel R, Lütke Eversloh C, Ternes TA. Biotransformation of the UV-filter sulisobenzone: challenges for the identification of transformation products. Environ Sci Technol. 2013 Jul 2;47(13):6819-28. doi: 10.1021/es400451w. Epub 2013 Jun 19. allergic contact sensitivity to sulisobenzone. Arch Dermatol. 1971 Oct;104(4):446-8. doi: 10.1001/archderm.104.4.446. 23(4):211-8. doi: 10.1046/j.1467-2494.2001.00089.x. 31(4):273-9. doi: 10.3109/15569527.2011.647181. Epub 2012 Jan 18. 369(7-8):638-41. doi: 10.1007/s002160100701. 101(1):370-377. doi: 10.1016/j.marpolbul.2015.10.015. Epub 2015 Nov 2. 23(10):2671. doi: 10.3390/molecules23102671. 8: Yang P, Kong D, Ji Y, Lu J, Yin X, Zhou Q. Chlorination and chloramination of benzophenone-3 and benzophenone-4 UV filters. Ecotoxicol Environ Saf. 2018 Nov 15;163:528-535. doi: 10.1016/j.ecoenv.2018.07.111. Epub 2018 Aug 1. 651(Pt 2):2391-2399. doi: 10.1016/j.scitotenv.2018.10.148. Epub 2018 Oct 11. 52(3):1262-1269. doi: 10.1021/acs.est.7b05014. Epub 2018 Jan 26. 25(32):32549-32561. doi: 10.1007/s11356-018-3171-z. Epub 2018 Sep 21. 354(2):195-202. doi: 10.1124/jpet.115.223644. Epub 2015 May 27. 635:1302-1307. doi: 10.1016/j.scitotenv.2018.04.115. Epub 2018 Apr 24. 16(3):628-33. doi: 10.1002/cphc.201402703. Epub 2015 Jan 7.
合成参考文献
摘要:Journal of the American College of Toxicology., 2(5)(35), 1983 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994) 摘要:Cosmetic Ingredient Review; Final Report on the Safety Assessment of Benzophenones-1, -3, -4, -5, -9, and -11; Journal of the American College of Toxicology 2 (5): 35-78 (1983). Available form, as of September 12, 2013: 摘要:Mill T, Mabey W; p 209 in Environmental Exposure From Chemicals, Volume I, Neely WB, Blau GE, eds, Boca Raton, FL: CRC Press Inc (1985) 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118