CAS: 3689-76-7; Chlormidazole

📜N-(2-Acetylphenyl)-4-Methylbenzenesulfonamide置于碘苯二乙酸,氨,十六烷基三甲基溴化铵,Potassium Carbonate,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 26.5H,反应生成氯苄达唑
参考文献:高价碘介导的氧化重排合成苯并恶唑和苯并咪唑
标题:高价碘介导的氧化重排合成苯并恶唑和苯并咪唑
摘要:已经开发出贝克曼型重排邻羟基和邻氨基芳基nh酮亚胺,分别制备苯并恶唑和n-Ts苯并咪唑.通过使氨与相应的酮缩合,可以容易地制备酮亚胺衍生物,并且发现(二乙酰氧基碘)苯可作为有效的氧化剂来触发[1,2]-芳基向形成所需杂环的迁移.根据取代模式,结果揭示了另一种可能形成苯并异恶唑或1 H-吲唑的机理.Beckmann型重排策略用于合成含苯并咪唑的生物相关靶标,如氯咪唑和克立咪唑.
Doi:10.1016/j.Tet.2014.11.066

专利信息

专利号:US-9382288-B2
优先权日:2010-10-06
标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
发明人：BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

专利号:US-11944609-B1
优先权日:2023-06-16
标题:Antifungal ionic liquid and Amphotericin B combination
发明人：RATHER SAMI-ULLAH; WANI MOHMMAD YOUNUS; BAMUFLEH HISHAM S; ALHUMADE HESHAM; SAEED USMAN; TAIMOOR AQEEL AHMAD; ALALAYAH WALID M; RATHER IRFAN AHMAD
权利人:KING ABDULAZIZ UNIVERISTY; UNIV KING ABDULAZIZ
摘要:Provided herein are ionic liquids that can be used as antifungal agents alone or in combination with Amphotericin B. Also disclosed are methods of synthesis of the ionic liquids and inhibiting fungal growth and methods of treating fungal infections using the disclosed compounds. The disclosure provides antifungal agents that potentiate the antifungal activity of Amphotericin B, a commonly used antifungal drug that could be used alone or in combination. This combination will help control and combat the infections caused by drug resistant Candida. auris in immunocompromised patients.

专利号:CN-106866543-B
优先权日:2017-04-16
标 题 :A kind of method for catalyzing synthesis of benzimidazole compound under microwave irradiation in aqueous phase

专利号:CN-106866543-A
优先权日:2017-04-16
标题:A kind of method that catalyzes the synthesis of benzimidazole compound under microwave irradiation in aqueous phase

专利号:US-7199128-B2
优先权日:2005-02-02
标题 :8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
发明人：BRADBURY BARTON J; WILES JASON ALLAN; DESHPANDE MILIND; WANG QIUPING; HASHIMOTO AKIHIRO; LUCIEN EDLAINE
权利人:ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compounds and salts of Formula I and Formula II: n nwhich possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein.n n Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

专利号:US-2009012071-A1
优先权日:2007-04-23
标 题 :4-substituted-1h-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2h,9h)-diones and related compounds as anti-infective agents
发明人：BRADBURY BARTON JAMES; DESHPANDE MILIND; HASHIMOTO AKIHIRO; KIM HA YOUNG; LUCIEN EDLAINE; PAIS GODWIN; PUCCI MICHAEL JOHN; WANG QIUPING; WILES JASON ALLAN
权利人:ACHILLION PHARMACEUTICALS INC
摘要:The present invention provides compounds of the formula that possess antimicrobial activity. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity. Particular compounds provided herein are also potent and/or selective inhibitors of microbial DNA synthesis and reproduction. The invention provides anti-microbial compositions, including pharmaceutical compositions, containing a compound of the invention and one or more or more carriers. The invention provides pharmaceutical compositions containing a 4-substituted- 1 H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound as the only active agent or in combination with one or more other active agents. The invention provides methods for treating or preventing microbial infections, preferably animals, by administering an effective amount of a 4-substituted- 1 H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound to an organism suffering from or susceptible to microbial infection. The invention also provides methods of inhibiting microbial growth and survival by applying an effective amount of a 4-substituted- 1 H-isothiazolo[5,4-b][1,4]oxazino[2,3,4-ij]quinoline-7,8(2H,9H)-dione or related compound.