CAS: 23745-86-0; Potassium,2-Fluoroacetate

📜氟乙酸乙酯置于氢氧化钾体系中,用 乙醇 用作溶剂,以66%的收率获得氟乙酸钾
参考文献:Synthesis And Biological Evaluation Of A Chitobiose-Based Peptide N-Glycanase Inhibitor Library
标题:Synthesis And Biological Evaluation Of A Chitobiose-Based Peptide N-Glycanase Inhibitor Library
摘要:Peptide N-Glycanase (Pngase),The Enzyme Responsible For The Deglycosylation Of N-Linked Glycoproteins,Has An Active Site Related To That Of Cysteine Proteases. Chitiobiose Was Equipped With Electrophilic Traps Often Used In Cysteine Protease Inhibitors,And The Resulting Compounds Were Evaluated As Pngase Inhibitors. We Found That The Electrophilic Trap Of The Inhibitor Has A Great Influence On The Potency Of The Compounds With The Chloromethyl Ketone Inhibitor Being The First Potent C-Glycoside-Based Pngase Inhibitor.
Doi:10.1021/jo801906S