CAS: 2366-52-1; 1-Fluorobutane

上下游产品

CAS号109-65-9 正溴丁烷 | CAS号542-69-8 碘代正丁烷 | CAS号109-72-8 正丁基锂 | CAS号693-04-9 正丁基氯化镁 | CAS号71-36-3 正丁醇 | CAS号106-93-4 1,2-二溴乙烷 | CAS号624-73-7 1,2-二碘乙烷 | CAS号358-36-1 n-butyl 2-chlor... | CAS号106-98-9 正丁烯 | CAS号778-28-9 对甲苯磺酸正丁酯 | CAS号402846-78-0 1-丁基-2,3-二甲基咪唑四氟硼酸盐 | CAS号174501-65-6 1-丁基-3-甲基咪唑四氟硼酸盐 | CAS号462-73-7 1-氯-4-氟丁烷 | CAS号691-40-7 3-chloro-1-fluo... | CAS号7664-39-3 氟化氢

📜正溴丁烷置于potassium Fluoride体系中,用 环丁砜 用作溶剂,化学反应 5.0H,以69%的收率获得氟化丁基
参考文献:微波光谱法和从头算计算的1-氟丁烷的构象平衡和势能面
标题:微波光谱法和从头算计算的1-氟丁烷的构象平衡和势能面
摘要:1-Freebutane的五个可能构象中的四个(gt,Tt,Tg和gg)的旋转光谱已通过结合自由射流和常规微波光谱法确定.使用6-31G(d)和6-311G(d,P)基集并使用b3Lyp(3Df,3Pd)密度泛函方法在理论上的mp2(完整)级别上进行了几何优化.在qcisd(t)/ 6-311G(d,P)的理论水平上计算五个旋转异构体的相对稳定性.尽管从头算计算表明未观测到的gg'构象异构体比至少一个观测到的构象异构体稳定,但无法检测其旋转光谱.Gt和tg分别是最稳定和最不稳定的物种.通过常规微波光谱研究了四个构象体的几个振动卫星的旋转光谱.总体构象平衡由骨骼扭转mec-Cc和fc-Cc的二维势能面控制,该结构已通过弹性模型分析根据相对构象和振动能间隔的实验值进行了评估,以及在构象变化和振动激发时第二惯性矩的移动.第五个稳定构象异构体(gg')的相对能量通过柔性模型计算确定为333 Cm(
Doi:10.1002/1521-3765(20000818)6:16<3018::Aid-Chem3018>3.0.Co;2-L

专利信息

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-4523022-A
优先权日:1983-07-07
标 题:Analogs of the antibiotic spectinomycin
发明人：THOMAS RICHARD C
权利人:UPJOHN CO
摘要:The present invention concerns the novel, sugar-ring expansion for synthesis of novel analogs of spectinomycin or C-6' analogs of spectinomycin from known aminomethyldihydrospectinomycin and analogs thereof. Additionally, the invention concerns the novel synthesis of novel 7 membered sugar-ring analogs of dihydrospectinomycin and C-6' analogs thereof from novel 7 membered sugar-ring spectinomycin and C-6' analogs thereof by treatment with NaBH4.

专利号:US-8461298-B2
优先权日:2004-11-01
标 题:Compositions and methods for modification of biomolecules
发明人：BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL
权利人:BERTOZZI CAROLYN R; AGARD NICHOLAS J; PRESCHER JENNIFER A; BASKIN JEREMY MICHAEL; UNIV CALIFORNIA
摘要:The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

专利号:US-11091445-B2
优先权日:2016-10-24
标题 :Compounds, process for obtaining the compounds, pharmaceutical composition, use of the compounds and method for treating psychiatric disorders and/or sleep disorders
发明人：RUCH WERNECK GUIMARÃES CRISTIANO; FELYPE ZANETI DE AZEVEDO HATYLAS; MASCARELLO ALESSANDRA; WATANABE DA COSTA RENATA; FREIRE TORRES RUSSO VALTER; MANNOCHIO DE SOUZA RUSSO ELISA
权利人:ACHE LABORATORIOS FARMACEUTICOS SA
摘要:The present disclosure relates to novel and inventive pharmacologically active benzimidazole derivative compounds, which surprisingly have high affinity for melatonin MT1 and MT2 receptors and low affinity for CYP450 complex enzymes, specially CYP1A2. The present invention also relates to novel and inventive routes of synthesis of these compounds, pharmaceutical compositions comprising the compounds and the use of these compounds in the treatment of individuals affected by psychiatric disorders and/or sleep disorders related to these receptors (specially depression, anxiety, circadian cycle disorders), in addition to a process for producing the composition.