专利号:US-6812320-B2 优先权日:2002-03-25 标题:Method for copolyestercarbonate synthesis 发明人:SILVA JAMES MANIO; DARDARIS DAVID MICHEL; O'NEIL GREGORY ALLEN; SYBERT PAUL DEAN; SU ZHAOHUI 权利人:GEN ELECTRIC 摘要:Thermally stable block copolyestercarbonates comprising chain members derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety, said polymer being substantially free of anhydride linkages linking at least two mers of the polyester chain segments, are prepared by a method comprising the steps of: (a) preparing a hydroxy-terminated polyester intermediate comprising structural units derived from at least one dihydroxy-substituted aromatic hydrocarbon moiety and at least one aromatic dicarboxylic acid moiety; and (b) conducting a reaction of the polyester intermediate with phosgene in a reaction mixture comprising water, a substantially water-immiscible organic solvent, and a base, wherein base and phosgene are added simultaneously to the reaction mixture at a substantially constant molar ratio of base to phosgene for a time period of at least about 60% of the total amount of phosgene added.
专利号:RU-2024511-C1 优先权日:1986-04-17 标 题 :Method of synthesis of e-isomers of acrylic acid derivatives
专利号:JP-2005521765-A 优先权日:2002-03-25 标题 :Synthesis of copolyestercarbonate
专利号:ES-2290440-T3 优先权日:2002-03-25 标题 :METHOD FOR SYNTHESIS OF COPOLIESTERCARBONATES.
专利号:US-6090805-A 优先权日:1997-06-18 标 题 :Tocolytic oxytocin receptor antagonists 发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; PERLOW DEBRA S; STAUFFER KENNETH; FREIDINGER ROGER M 权利人:MERCK & CO INC 摘要:This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
专利号:US-5968938-A 优先权日:1997-06-18 标 题 :Piperazine oxytocin receptor antagonists 发明人:WILLIAMS PETER D; SPARKS MICHELLE A; BELL IAN; GUARE JR JAMES P; FREIDINGER ROGER M 权利人:MERCK & CO INC 摘要:This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
参考文献:10.1016/j.ejmech.2008.04.019 摘要:Lv P, Xiao Z, Fang R, Li H, Zhu H, Liu C. Synthesis, characterization and structure–activity relationship analysis of novel depsides as potential antibacterials. European Journal of Medicinal Chemistry. 2009 Apr;44(4):1779–87. doi: 10.1016/j.ejmech.2008.04.019.