专利号:US-2012029226-A1 优先权日:2009-02-06 标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives 发明人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE 摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.
专利号:US-4396542-A 优先权日:1980-02-14 标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production 发明人:WENGER ROLAND 权利人:SANDOZ LTD 摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.
专利号:US-4554351-A 优先权日:1980-02-14 标 题:Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production 发明人:WENGER ROLAND 权利人:SANDOZ LTD 摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.
专利号:WO-2007064291-A1 优先权日:2005-11-30 标 题:Method and compounds for rna synthesis 发明人:CHATTOPADHYAYA JYOTI 权利人:CHATTOPADHYAYA JYOTI 摘要:The 2-(4-tolylsulfonyl)ethoxymethyl (TEM) as a new 2'-OH protecting group is reported for the RNA synthesis on the solid support using the phosphoramidite chemistry. The usefulness of the 2'-0-TEM group is exemplified by the synthesis of 12 different oligo-RNAs of various sizes (14-38nt long). The stepwise coupling yield varied from 97 - 99 % with an optimized coupling time of 120s. Synthesis of all four pure phosphoramidite building blocks are also described. Two new reliable parameters, δc2' - δc3s and δn2' - δH3' have been suggested for the characterization of isomeric 2'-0-TEM and 3'-0-TEM as well as other isomeric mono 273 '-protected ribonucleoside derivatives. The most striking feature of this strategy is that the crude RNA prepared using our 2'-0-TEM strategy is sufficiently pure (>90 %) for molecular biology research without any additional purification step, thereby making oligo-RNAs easily available at a relatively low cost, saving both time and lab resources.
专利号:US-6906046-B2 优先权日:2000-12-22 标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes 发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY 权利人:CELLTECH R & D INC 摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.
专利号:WO-2014171894-A1 优先权日:2013-04-18 标 题 :Synthesis of cyclic carbonates 发明人:ZHANG YUGEN; REITHOFER MICHAEL R; SUM YIN NGAI 权利人:AGENCY SCIENCE TECH & RES 摘要:The present invention provides a method of synthesizing a cyclic carbonate comprising the step of reacting an alcohol with carbon dioxide.in the presence of a base.
参考标题:Synthesis Of Cyclic Carbonates With Carbon Dioxide And Cesium Carbonate 作者:Michael R. Reithofer,Yin Ngai Sum,Yugen Zhang 摘要:Cyclic Carbonates Are Important Compounds For The Synthesis Of Biocompatible Polymers And Linear Dialkyl Carbonates, As Well As Solvents And Electrolytes. We Report Here The Synthesis Of Such Compounds From Easily Accessible Starting Materials With Carbon Dioxide As A C1 Source And Caesium Carbonate As The Base. This New Methodology Is Able To Yield 5- And 6-Membered Cyclic Carbonates Very Efficiently
合成参考文献
参考文献:10.1016/j.bmc.2012.02.014 摘要:Carta F, Maresca A, Scozzafava A, Supuran CT. Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII. Bioorg Med Chem. 2012 Apr 01;20(7):2266–73. doi: 10.1016/j.bmc.2012.02.014.