CAS: 22381-54-0; 2-Tosylethanol

该化合物是一种有机化合物,其特点是存在附属于一个苯基环和乙醇混合物的磺酰基组,该化合物具有与一个半甲基代苯基组相联系的磺酰基功能组(-SO2),该组有助于其独特的化学特性.分子乙醇部分中的羟基(-OH)组的存在会增加其极性,使其在水和酒精等极溶剂中溶解. 磺酰基组还可以参与各种化学反应,包括核循环代代用和增加电荷化合物,使该化合物在合成有机化学中具有灵敏性.此外,苯基的亚甲基代用会影响该化合物的再活性和与生物系统的互动,有可能影响其药理特性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号13290-16-9 2-(对甲苯硫代)-乙醇 | CAS号699-02-5 2-(4-甲基苯基)乙醇 | CAS号75-21-8 环氧乙烷 | CAS号824-79-3 对甲苯亚磺酸钠 | CAS号107-07-3 2-氯乙醇 | CAS号106-45-6 4-甲基苯硫酚 | CAS号5535-52-4 对甲苯基乙烯基砜 | CAS号87943-26-8 2-(4-methylphen... | CAS号2631-14-3 2-[p-Tolylsulfo... | CAS号22952-14-3 1-methyl-4-[2-(... | CAS号96-49-1 碳酸乙烯酯 | CAS号1538-98-3 1-(diazomethyls... | CAS号21079-01-6 Glycine,N-[(phe... | CAS号651728-12-0 2-(4-methylphen... | CAS号651728-19-7 2-(4-methylphen... | CAS号651728-72-2 2-(4-methylphen... | CAS号6739-66-8 2-(4-methylphen... | CAS号86653-04-5 2-(4-methylphen... | CAS号94460-95-4 Ethanol,2-[(4-m... | CAS号5535-52-4 对甲苯基乙烯基砜

合成工艺路线路线简述

  • 合成目标产物 2-[(4-Methylphenyl)Sulfonyl]Ethanol 主要起始原料 2-(4-Methylphenyl)Ethanol
  • (文献来源)合成步骤主要原料 2-(4-Methylphenyl)Ethanol
📜2-(4-甲基苯基)乙醇 以 水,溶剂黄146 用作溶剂,化学反应 0.83H,以96.3%的收率获得2-(对甲苯磺酰)乙醇
参考文献:Wo2007/64291
标题:Wo2007/64291

海关参考信息

专利信息


专利号:US-2012029226-A1
优先权日:2009-02-06
标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives
发明人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.

专利号:US-4396542-A
优先权日:1980-02-14
标 题 :Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人:WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:US-4554351-A
优先权日:1980-02-14
标 题:Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
发明人:WENGER ROLAND
权利人:SANDOZ LTD
摘要:A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

专利号:WO-2007064291-A1
优先权日:2005-11-30
标 题:Method and compounds for rna synthesis
发明人:CHATTOPADHYAYA JYOTI
权利人:CHATTOPADHYAYA JYOTI
摘要:The 2-(4-tolylsulfonyl)ethoxymethyl (TEM) as a new 2'-OH protecting group is reported for the RNA synthesis on the solid support using the phosphoramidite chemistry. The usefulness of the 2'-0-TEM group is exemplified by the synthesis of 12 different oligo-RNAs of various sizes (14-38nt long). The stepwise coupling yield varied from 97 - 99 % with an optimized coupling time of 120s. Synthesis of all four pure phosphoramidite building blocks are also described. Two new reliable parameters, δc2' - δc3s and δn2' - δH3' have been suggested for the characterization of isomeric 2'-0-TEM and 3'-0-TEM as well as other isomeric mono 273 '-protected ribonucleoside derivatives. The most striking feature of this strategy is that the crude RNA prepared using our 2'-0-TEM strategy is sufficiently pure (>90 %) for molecular biology research without any additional purification step, thereby making oligo-RNAs easily available at a relatively low cost, saving both time and lab resources.

专利号:US-6906046-B2
优先权日:2000-12-22
标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes
发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY
权利人:CELLTECH R & D INC
摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.

专利号:WO-2014171894-A1
优先权日:2013-04-18
标 题 :Synthesis of cyclic carbonates
发明人:ZHANG YUGEN; REITHOFER MICHAEL R; SUM YIN NGAI
权利人:AGENCY SCIENCE TECH & RES
摘要:The present invention provides a method of synthesizing a cyclic carbonate comprising the step of reacting an alcohol with carbon dioxide.in the presence of a base.

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品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Synthesis Of Cyclic Carbonates With Carbon Dioxide And Cesium Carbonate
作者:Michael R. Reithofer,Yin Ngai Sum,Yugen Zhang
摘要:Cyclic Carbonates Are Important Compounds For The Synthesis Of Biocompatible Polymers And Linear Dialkyl Carbonates, As Well As Solvents And Electrolytes. We Report Here The Synthesis Of Such Compounds From Easily Accessible Starting Materials With Carbon Dioxide As A C1 Source And Caesium Carbonate As The Base. This New Methodology Is Able To Yield 5- And 6-Membered Cyclic Carbonates Very Efficiently

合成参考文献


参考文献:10.1016/j.bmc.2012.02.014
摘要:Carta F, Maresca A, Scozzafava A, Supuran CT. Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII. Bioorg Med Chem. 2012 Apr 01;20(7):2266–73. doi: 10.1016/j.bmc.2012.02.014.
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