CAS: 202865-71-2; 5-Bromo-2-Fluorocinnamic Acid

上下游产品

malonic acid 5-bromo-2-fluorobenzaldehyde 3-(5-bromo-2-fluorophenyl)-N,N-dimethylpropan-1-amine 9-chloro-2-({3-[3-(dimethylamino)propyl]-4-fluorophenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 9-chloro-2-({3-[3-(dimethylamino)propyl]-4-fluorophenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione

丙二酸,5-溴-2-氟苯甲醛置于哌啶,吡啶体系中,化学反应生成5-溴-2-氟肉桂酸
参考文献:Rh(I)-催化不对称 C-H 芳基化的明确机理及平面手性二茂铁的简便合成
标题:Rh(I)-催化不对称 C-H 芳基化的明确机理及平面手性二茂铁的简便合成
摘要:机理引导的反应开发是化学中广受认可的研究范式,因为机理知识的融合将加速新合成方法的发现.低价过渡金属如 Pd(0)-和 Rh(I)-催化的 C-H 与芳基(假)卤化物的芳基化反应是两种不同芳基伙伴的排他性交叉偶联的促成反应.然而,与 Pd(0) 催化的情况不同,Rh(I) 催化的 C-H 芳基化的机理尚未得到充分探索.芳基 C-H 活化和芳基(假)卤化物的氧化加成的基本步骤的顺序仍不清楚.在此,我们报告了对 Rh(I) 催化的 2-吡啶基二茂铁和芳基溴化物之间的分子间不对称 C-H 芳基化的明确机制理解的综合实验和计算研究.催化循环中每个基本步骤的识别以及关键中间体和过渡态的结构表征允许合理设计和开发具有挑战性的分子内反应.该反应模式的成功实现为平面手性分子的简便合成奠定了基础[m ]Ferrocenophanes ( M = 6-8),一类很少探索的目标分子,具有应变结构和有趣的分子拓扑结构.
Doi:10.1021/jacs.2C13542

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-114230519-B
优先权日:2021-12-06
标题:A class of pleuromutilin cinnamate compounds with anti-drug-resistant bacteria activity and synthesis method and application thereof

专利号:CN-114230519-A
优先权日:2021-12-06
标 题:A class of pleuromutilin cinnamate compounds with anti-drug-resistant bacteria activity and its synthesis method and application