CAS: 16177-21-2; Sodium Dl-Glutamate

上下游产品

L-Pyroglutamic acid α-ketoglutaric acid disodium salt(S)-1-Pyrrolidin-2-yl-methanol (S)-Pyroglutaminol sodium L-pyroglutamate N-2-ethylhexanoyl-L-glutamic acid N,N'-(dibutylamide)

专利信息

专利号:US-4427587-A
优先权日:1982-11-10
标 题:Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
发明人：KANEKO TAKUSHI; WONG HENRY S L
权利人:BRISTOL MYERS CO
摘要:A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.

专利号:US-5302520-A
优先权日:1990-09-25
标 题:Enzymatic synthesis of isotopically labeled carbohydrates
发明人：GOUX WARREN J
权利人:UNIV TEXAS
摘要:The present invention relates to a general method of enzymatic synthesis of isotopically labeled carbohydrates, sugars and nucleosides. Labeled citric acid cycle intermediates, amino acids and ribose mononucleotides may be rapidly and conveniently synthesized from labeled pyruvate, lactate or L-alanine. The method employs a novel nicotinamide dinucleotide regeneration system which permits use of low NADH levels. The method may be manipulated to allow labeling at a variety of carbon/hydrogen sites.

专利号:US-2021047609-A1
优先权日:2018-01-26
标 题 :Method For Promoting Synthesis Of Sorbitol Dehydrogenase And Coenzyme Pyrroloquinoline Quinone From Gluconobacter Oxydans
发明人：ZHENG YUGUO; KE XIA; LU YANGHUI; HU ZHONGCE; WU YANG
权利人:UNIV ZHEJIANG TECHNOLOGY; ZHEJIANG MED XINCHANG PHARM
摘要:The present invention discloses a method for promoting the fermentation of Gluconobacter oxydans to produce D-sorbitol dehydrogenase and pyrroloquinoline quinone. The method comprises: Gluconobacter oxydans is inoculated to a fermentation culture medium, fermented and cultured under the conditions of 28-32° C. and 150-180 rpm for 6-24 hours, the fermented solution is centrifuged, and wet bacteria are collected, thus acquiring bacteria cells containing D-sorbitol dehydrogenase and pyrroloquinoline quinone. The method promotes the synthesis of coenzyme pQQ and the enzyme activity of per unit volume D-sorbitol dehydrogenase, Gluconobacter oxydans cultured and acquired using the method is biotransformed to synthesize miglitol precursor 6-deoxy-6-amino(N-hydroxyethyl)-α-L-furan sorbose (6NSL), the conversion progress of the product 6NSL is increased by 21-35%, and a biotransformation step cycle is reduced from 48 hours to 36 hours. In addition, under a same substrate concentration (60 g/L), the cumulative concentration of the product 6NSL is increased by 10 g/L or more.

专利号:WO-2025077487-A1
优先权日:2023-10-12
标 题 :ENZYME SELF-ASSEMBLY COMPLEX FOR SUPPLYING α-KETOGLUTARATE AND USE THEREOF IN CATALYTIC SYNTHESIS OF 4-HYDROXYISOLEUCINE
发明人：NIE YAO; XU YAN; LIU HUAN
权利人:UNIV JIANGNAN
摘要:An enzyme self-assembly complex for supplying α-ketoglutarate and the use thereof in catalytic synthesis of 4-hydroxyisoleucine, which belong to the technical field of biocatalysis. Glutamate oxidase catalyzes the production of α-KG from glutamate, and catalase decomposes the by-product H 2 0 2 , the RIAD-RIDD interaction and merged state resulting from covalent ligation can mediate the characteristics of a higher-order structure of a plurality of self-assembly enzymes, and an LGOX/KatG self-assembly system is constructed in vitro through the affinity of short peptides, enabling the in situ elimination of H 2 O 2 and relieving the inhibition of H 2 O 2 on Fe(II)/α-KG DOs. The system is cascaded with IDO to achieve efficient and high-yield production of 4-HIL in a one-pot system, with a maximum yield of 95% at the substrate concentration of 100 mM.

专利号:EP-0303364-A1
优先权日:1987-08-10
标 题:Cloning and nucleotide sequence determination of the isopenicillin N synthetase gene from streptomyces clavuligerus
发明人：JENSEN SUSAN E; WESTLAKE DONALD W S; LESKIW BRENDA K; AHARONOWITZ YAIR DEP OF MIBROB; MEVARECH MOSHEIR DEP OF MIBROB
权利人:UNIV ALBERTA
摘要:The gene coding for the enzyme Isopenicillin N Synthetase (IPNS) isolated from the prokaryote Streptomyces clavuligerus is cloned and sequenced. The corresponding amino acid sequence is also determined. The enzyme IPNS controls the rate of synthesis of the β-­lactam family of antibiotics. The nucleotide sequence is incorporated into a vector to effect a transformation of a suitable host microorganism. Such a transformed microorganism is useful in making in vitro synthesis of the β-lactams more practical and in whole cell fermentations to produce higher levels of β-lactams.

专利号:US-11203780-B2
优先权日:2016-08-25
标 题 :Process for the enzymatic synthesis and amplification of nucleic acids
发明人：CHERKASOV DMITRY; BASLER NORBERT; BECKER CLAUS; HESS HANS-JOERG; MUELLER-HERMANN ANDREAS
权利人:AGCT GMBH
摘要:A method for amplification of nucleic acids in which substantially use is made of the fact that a pre-defined nucleic acid chain (target sequence) can be multiplied/amplified in the presence of a target sequence-specific activator oligonucleotide. The target sequence-specific activator oligonucleotide causes the separation of re-synthesized complementary primer extension products by strand displacement, so that a new primer oligonucleotide can attach to the respective template strand. The thus formed complex of a primer oligonucleotide and a template strand can initiate a new primer extension reaction. The thus formed primer extension products in turn function as templates, so that an exponential amplification reaction results. Amplification of a particular target sequence takes place more efficiently in case of perfect match complementary base pair formation between the activator oligonucleotide and the corresponding target sequence. Mismatches between the activator oligonucleotide and a particular target sequence can result in less efficient amplification. The efficiency of synthesis of perfect match target sequences and mismatch sequences can be measured and compared.