CAS: 15084-51-2; 4-Tert-Butylbenzenesulfonyl Chloride

该化合物是一种有机化合物,其特征是附于一个三丁基代苯环的全氟辛烷磺酸功能组,该化合物一般是无色的黄色液体,以其强烈的反作用而闻名,特别是由于可随时参与核生殖替代反应的全氟氯化物组而闻名;它通常用作有机合成的磺酰胺剂,便于将磺酰胺组引入各种子体;散装三丁基氯基组的存在,增强了其消毒特性,影响其在化学反应中的再活动性和选择性;此外,四丁基苯基硫化氯对湿气敏感,应谨慎处理,因为它能在水解过程中释放盐酸;由于这种化合物具有腐蚀性并具有潜在的健康危害,因此在与该化合物合作时,适当的安全防范措施,包括使用个人防护设备,至关重要.

结构式图片

相似化合物

2905-26-2 16712-69-9 54997-90-9

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    4-(Tert-Butyl)Benzenesulfonohydrazide置于n-氯代丁二酰亚胺体系中,用 乙腈 用作溶剂,化学反应 2.0H,以86%的收率获得对叔丁基苯磺酰氯
    参考文献:从磺酰肼轻松合成磺酰氯/溴化物
    标题:从磺酰肼轻松合成磺酰氯/溴化物
    摘要:描述了一种使用 Nxs(x = Cl 或 Br)从磺酰肼高效合成磺酰氯/溴化物并在后期转化为几个其他官能团的简单快速方法.多种亲核试剂可以参与这种转化,从而可以合成复杂的磺酰胺和磺酸盐.在大多数情况下,这些反应具有高度选择性,简单且清洁,以优异的收率提供产品.
    Doi:10.3390/molecules26185551

    海关参考信息

    专利信息


    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:CN-104892466-B
    优先权日:2015-04-30
    标 题 :Synthesis of a kind of aniline sulfonyl compound and its application as HIV virus inhibitor

    专利号:US-8034908-B2
    优先权日:2003-02-14
    标 题:Glycolipids and synthetic method thereof as well as their synthetic intermediates, and synthetic method thereof
    发明人:ANNOURA HIROKAZU; MURATA KENJI; YAMAMURA TAKASHI
    权利人:JAPAN GOVERNMENT
    摘要:Novel glycolipid derivatives, where the substituent of the sphingosine base part is a short carbon chain alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group and efficient synthetic methods for practical mass production of the same and intermediates useful for the synthesis of these compounds. n Glycolipids having the formula (I): n nwhere R 3 indicates a substituted or unsubstituted C 1 to C 7 linear alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted aryl group, or substituted or unsubstituted aralkyl group and R 8 indicates a substituted or unsubstituted C 1 to C 35 alkyl group, substituted or unsubstituted aryl group or substituted or unsubstituted aralkyl group are chemically synthesized.

    专利号:US-10246411-B2
    优先权日:2014-10-29
    标 题:(Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents
    发明人:KAMAL AHMED; RASALA MAHESH; RATNA REDDY CHALLA; BHARATH KUMAR GAJJELA; SASTRY VISWESWARA; BASHA SHAIK ANVER; SANTHOSH REEDY VANGALA
    权利人:COUNCIL SCIENT IND RES
    摘要:This present invention relates to (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides of general formula A. The invention also provides the synthesis of (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.

    专利号:CN-109503693-A
    优先权日:2018-12-12
    标 题:A new process for efficient synthesis of Aramchol using cholic acid and arachidic acid as raw materials
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    主要参考文献

    参考标题:Diversity Oriented Clicking (Doc): Divergent Synthesis Of Sufexable Pharmacophores From 2‐substituted‐alkynyl‐1‐sulfonyl Fluoride (Sasf) Hubs
    作者:Christopher J. Smedley,Gencheng Li,Andrew S. Barrow,Timothy L. Gialelis,Marie‐claire Giel,Alessandra Ottonello,Yunfei Cheng,Seiya Kitamura,Dennis W. Wolan,K. Barry Sharpless,John E. Moses |发布日期:2020.7.20
    摘要:Diversity Oriented Clicking (Doc) Is A Unified Click‐approach For The Modular Synthesis Of Lead‐like Structures Through Application Of The Wide Family Of Click Transformations. Doc Evolved From The Concept Of Achieving "Diversity With Ease" , By Combining Classic C−c π‐bond Click Chemistry With Recent Developments In Connective Sufex‐technologies. We Showcase 2‐substituted‐alkynyl‐1‐sulfonyl Fluorides

    合成参考文献


    摘要:Kashemirov, B. A.; Błażewska, K.; Justyna, K.; Lyu, J.; McKenna, C. E., Science of Synthesis Knowledge Updates, (2021) 1, 414.
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