CAS: 1404-88-2; Tyrothricin

该化合物是聚虫胺的一种复杂混合物,主要以其抗生素特性而闻名,由细菌巴西柳叶生产,对一系列抗菌性细菌有效,在临床应用中,特别是在热剂制剂中,具有价值.蒂洛特丁展示了独特的行动机制,干扰细菌细胞膜,导致细胞解析.该物质通常用于治疗局部感染,并经常存在于喉咙叶和热液中,其特点是水溶性低,限制了其系统吸收,降低了系统副作用的风险.亚特朗西因一般都受到很好的缓解,但和所有抗生素一样,可能会导致某些人的过敏反应.由于抗生素抗药性的发展潜力,其使用往往局限于特定应用.

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    专利号:US-12123041-B2
    优先权日:2018-09-21
    标 题:Method for the production of amino sugar-containing products
    发明人:MAERTENS JO; BAUWENS DAVID; VAN BELLEGEM WOUTER; COUSSEMENT PIETER; DUCHI DRIES; DE MEY MARJAN
    权利人:UNIV GENT
    摘要:A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.

    专利号:US-9382288-B2
    优先权日:2010-10-06
    标题 :Derivatives of steroid benzylamines, having an antiparasitic antibacterial, antimycotic and/or antiviral action
    发明人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO
    权利人:BECKER KATJA; KRIEG REIMAR; SCHÖNECKER BRUNO; UNIV GIESSEN JUSTUS LIEBIG
    摘要:The present invention relates to compounds derived from steroids of the general formula (I) n nwherein L represents a linker and R # represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9295731-B2
    优先权日:2013-04-01
    标题 :Cleavable drug conjugates, compositions thereof and methods of use
    发明人:NGUYEN MARK QUANG
    权利人:NGUYEN MARK QUANG
    摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:CN-116143891-A
    优先权日:2023-03-07
    标题:Application of transcription factor CeMyb108 in regulation and control of taro starch synthesis

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    主要参考文献


    1: Stauss-Grabo M, Atiye S, Le T, Kretschmar M. Decade-long use of the antimicrobial peptide combination tyrothricin does not pose a major risk of acquired resistance with gram-positive bacteria and Candida spp. Pharmazie. 2014 Nov;69(11):838-41. doi: 10.1099/mic.0.068734-0. Epub 2013 Aug 20. doi: 10.1159/000439439. Epub 2015 Oct 13. doi: 10.1159/000343907. Epub 2012 Nov 24. doi: 10.1007/s12272-014-0368-7. Epub 2014 Apr 10. Review. doi: 10.4014/jmb.1512.12037. German.
    15: Grossgebauer K, Hartmann D. [Antiviral activity of tyrothricin against Sendai virus in suspension tests (author's transl)]. Zentralbl Bakteriol Orig B. 1978 May;166(4-5):434-42. German. doi: 10.1039/c5np00035a. Review.
    18: DARLING D, BAUMEISTER CF. Tyrothricin in the treatment of the common cold. Arch Otolaryngol. 1947 Sep;46(3):395-7. Review. doi: 10.1016/S0140-6736(15)00840-5. Epub 2015 Nov 18.

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    摘要:S10 | SWISSPHARMA | Pharmaceutical List with Consumption Data | DOI:10.5281/zenodo.2623484
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