CAS: 139585-48-1; 2-Chloro-5-Methoxypyridine

相似化合物

856851-48-4 1204483-99-7 1206980-28-0

上下游产品

CAS号41288-96-4 2-氯-5-羟基吡啶 | CAS号74-88-4 碘甲烷 | CAS号10167-97-2 2-氨基-5-甲氧基吡啶 | CAS号638352-78-0 2-(2,5-二甲基-1H-吡... | CAS号477889-91-1 2-(2,5-DIMETHYL... | CAS号5350-93-6 2-氯-5-氨基吡啶 | CAS号89809-63-2 5-甲氧基皮考啉腈 | CAS号139585-64-1 5-甲氧基-2-(三甲基甲硅烷基)吡啶 | CAS号330473-71-7 3-Pyridinol,6-(... | CAS号53698-54-7 5-甲氧基-2-苯基吡啶

2-(2,5-二甲基-1H-吡咯-1-基)-5-甲氧基吡啶置于盐酸,盐酸羟胺,三乙胺,Sodium Nitrite体系中,用 乙醇,水 用作溶剂,化学反应 20.0H,反应生成2-氯-5-甲氧基吡啶
参考文献:通过改良的 Negishi 交叉偶联反应合成不同双取代的 2,2'-联吡啶
标题:通过改良的 Negishi 交叉偶联反应合成不同双取代的 2,2'-联吡啶
摘要:已经开发了通过应用改良的 Negishi 交叉偶联条件从取代的 2-溴-和 2-氯吡啶中获得许多不同二取代的 2,2'-联吡啶的通用实用方法.这些 2,2'-联吡啶带有多功能的官能团,可以进一步细化,如一些例子所示.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2003)
Doi:10.1002/ejoc.200300192

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:EP-1930323-A1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists

专利号:EP-1930323-B1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists

专利号:US-9962690-B2
优先权日:2014-04-27
标题:N-substituted pyridiniophosphines, processes for their preparation and their use
发明人：ALCARAZO MANUEL; WILLE CHRISTIAN; TINNERMANN HENDRIK
权利人:STUDIENGESELLSCHAFT KOHLE MBH
摘要:The present invention deals with the synthesis and applications of new cationic compounds being useful as metal ligands. Specifically, N-alkyl/aryl substituted pyridiniophosphines are prepared and used as ligands for transition metals. The so-obtained metal complexes and their use as catalysts in chemical synthesis is also described. It also worth mentioning that N-alkyl/aryl pyridiniophosphines can be synthesized through a short, scalable and highly modular route.

专利号:CN-106588758-B
优先权日:2016-11-08
标题 :Synthesis process of 2-hydrazinopyridine derivative