CAS: 135897-06-2; 5,6,7,8-Tetrahydro-13H-16-Oxa-4B,8A,14-Triaza-5,8-Methanodibenzo[b,H]Cycloocta[jkl]Cyclopenta[e]-As-Indacene-13,15(14H)-Dione
该化合物是一个复杂的有机化合物,其独特的多环形结构包括多个引信环形和氮原子.该化合物具有三联苯混合物的特性,有助于其潜在的生物活动.环氧化合物的存在表明,它可能参与各种化学反应,包括核循环攻击.其碳和氮原子的复杂安排表明,在材料科学,有机电子学或染色体中的潜在应用可能取决于其溶性和稳定性.该化合物的合成和再活性对有机化学具有兴趣,特别是在开发具有特定电子或光学特性的新化合物方面.需要进一步研究以充分阐明其特性,包括其光谱特性,包括其光谱特性,再生能,反应和在各领域的潜在用途.
- 英文名称5,6,7,8-Tetrahydro-13H-16-Oxa-4B,8A,14-Triaza-5,8-Methanodibenzo[b,H]Cycloocta[jkl]Cyclopenta[e]-As-Indacene-13,15(14H)-Dione
- 中文名称9,10,11,12-四氢-9,12-环氧-1H-二吲哚[1,2,3-fg:3',2',1'-kl]吡咯并[3,4-i][1,6]苯并重氮电影-1,3(2H)-二酮
- IUPAC名称5,6,7,8-tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione
- CAS编号135897-06-2
- MFCD编号:MFCD06411452
- FDA UNII编号:S6U3J3UP11
- 分子式:C24H15N3O3分子量:393.4
- 产品CID: 560554
- 产品分类生物化工 → 抑制剂
物理性质
上下游产品
12,13-二氢-5H-吲哚并[2,3-A]吡咯并[3,4-C]咔唑-5,7(6H)-二酮 Arcyriaflavin A 118458-54-1合成工艺路线路线简述
📜12,13-二氢-5H-吲哚并[2,3-A]吡咯并[3,4-C]咔唑-5,7(6H)-二酮,2,5-二甲氧基四氢呋喃,对甲苯磺酸,二氯甲烷 反应生成9,10,11,12-四氢-9,12-环氧-1H-二吲哚[1,2,3-Fg:3',2',1'-Kl]吡咯并[3,4-I][1,6]苯并重氮电影-1,3(2H)-二酮
参考文献:Kleinschroth,Jurgen;Hartenstein,Johannes;Schachtele,Christoph;Rudolph,+
标题:Kleinschroth,Jurgen;Hartenstein,Johannes;Schachtele,Christoph;Rudolph,+
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📌 第三方产品分析报告
主要参考文献
1: Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb;41(2):180-188.e4. doi: 10.1016/j.exphem.2012.10.007. Epub 2012 Oct 17.
2: Park JH, Kim WS, Kim JY, Park MH, Nam JH, Yun CW, Kwon YG, Jo I. Chk1 and Hsp90 cooperatively regulate phosphorylation of endothelial nitric oxide synthase at serine 1179. Free Radic Biol Med. 2011 Dec 15;51(12):2217-26. doi: 10.1016/j.freeradbiomed.2011.09.021. Epub 2011 Sep 25. doi: 10.1038/onc.2010.163. Epub 2010 May 17. doi: 10.1186/1479-5876-7-43.
5: Robles AI, Wright MH, Gandhi B, Feis SS, Hanigan CL, Wiestner A, Varticovski L. Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. Clin Cancer Res. 2006 Nov 1;12(21):6547-56. Review. Epub 2002 Sep 19.
合成参考文献
摘要:Jackson JR, Gilmartin A, Imburgia C, Winkler JD, Marshall LA, Roshak A. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 2000 Feb 01;60(3):566–72.
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
参考文献:10.1021/jm0256169
摘要:Zhu G, Conner SE, Zhou X, Shih C, Li T, Anderson BD, Brooks HB, Campbell RM, Considine E, Dempsey JA, Faul MM, Ogg C, Patel B, Schultz RM, Spencer CD, Teicher B, Watkins SA. Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027–30. doi: 10.1021/jm0256169.
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