CAS: 1206711-16-1; 4-(6-(4-Isopropoxyphenyl)Pyrazolo[1,5-A]Pyrimidin-3-yl)Quinoline
该化合物是一种合成有机化合物,属于一种类型的杂交循环化合物.该物质具有复杂的分子结构,其中包括一种与一种正对子-旋律-旋律粘合在一起的quinline核心,有助于其潜在的生物活动.一甲基乙氧基组的存在,增强了其亲脂性,有可能影响其溶性及在生物系统中的渗透性.这种化合物经常因其药用性质而受到调查,包括防炎,抗癌或抗微生物活动.分子的功能组的具体安排和三维整体相容性可以极大地影响其与生物目标的相互作用,使其成为对医药化学的兴趣对象.与许多合成化合物一样,了解其稳定性,再活性和潜在毒性对于评估其在研究和治疗环境中的适用性至关重要.
- 英文名称4-(6-(4-Isopropoxyphenyl)Pyrazolo[1,5-A]Pyrimidin-3-yl)Quinoline
- 中文名称4-[6-(4-丙-2-基氧基苯基)吡唑并[1,5-a]嘧啶-3-基]喹啉
- IUPAC名称4-(6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
- CAS编号1206711-16-1
- MFCD编号:MFCD18384963
- EINECS号:682-930-2
- FDA UNII编号:BVR5X3H6XM
- 分子式:C24H20N4O分子量:380.45
- 产品CID: 275894
- 产品分类生物化工 → 抑制剂 → TGF→beta/Smad信号通路抑制剂(TGF→beta/Smad)
物理性质
- 熔点178 °C
- 沸点178 °C
- 密度1.24±0.1 g/cm3(预测)
- pKa:3.34±0.46(预测)
- PSA:52.31
- LogP:5.3987
- 溶解性DMSO: Soluble5mg/mL, Clear (Warmed)
- 外观形态淡黄色至橙色粉末
- 储存条件2-8°C
- 产品应用该化合物是一种有选择性的BMP受体抑制剂,抑制BMP信号(IC50=100纳米),有选择地抑制BMP诱发SMAD1/5/8的活性;通过增加老鼠胚胎干细胞中的心肺细胞细胞细胞外生细胞分泌器,促进心脏分化;显著减少非小型细胞肺癌细胞细胞生长,迁移和入侵;在斑马鱼胚胎胚胎中给胚轴涂色,但不会干扰血管的产生;强烈抑制前孕外科植物的上皮细胞迁移;在带有A549基因移植的老鼠中,衰减蛋白肺肿瘤生长(5毫克/千克,I.P.);抑制自发性.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2933310010-吡啶
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2025177964-A1
优先权日:2023-11-30
标题 :Synthesis procedure of homopolymers and copolymers based on vinyl ionic liquids, n-vinylpyrrolidone or vinylpyridine and the methodology for their application as catalysts in alkylation reactions of isoparaffins and olefins
发明人：PAZ ARACELI VEGA; DOMà NGUEZ MERCEDES BAZALDUA; LUCERO DIEGO JAVIER GUZMà N; CORTEZ JOSÉ GONZALO HERNà NDEZ; ROBLES NOHEMà ORNELAS; PANTOJA JAVIER GUZMà N; PALOU RAFAEL MARTà NEZ
权利人:MEXICANO INST PETROL
摘要:The present disclosure relates to a procedure for the synthesis of polymers (homo and copolymers) of the poly (ionic liquid) (PIL) type. The homopolymers are derived from polyvinylimidazolium, polyvinylpyrrolidone or polyvinylpyridine and the copolymers from monomers of vinyl ionic liquids (ILs) are derived from imidazole and N-vinylpyrrolidone. The structural modification of these homopolymers and copolymers occurs by using strong inorganic acids such as sulfuric, chlorosulfonic and bromosulfonic, among others, and halide metallic salts such as AlCl3, FeCl3, CuCl, ZnCl2, and SnCl2. Also, these PILs are employed as catalysts in alkylation reactions between isoparaffins and olefins for producing alkylate gasoline.
专利号:US-6696438-B2
优先权日:1998-06-22
标题:Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:US-2003162768-A1
优先权日:1998-06-22
标 题:Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene. 2014 Jul 7. doi: 10.1038/onc.2014.189. [Epub ahead of print] doi: 10.1371/journal.pone.0090748. eCollection 2014.
5: Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis. 2013 Dec 9;8:190. doi: 10.1186/1750-1172-8-190.
6: Chang HM, Cheng JC, Klausen C, Leung PC. BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells. Mol Endocrinol. 2013 Dec;27(12):2093-104. doi: 10.1210/me.2013-1233. Epub 2013 Oct 18. doi: 10.1016/j.bbrc.2013.05.113. Epub 2013 Jun 6. doi: 10.1016/j.bmcl.2013.03.113. Epub 2013 Apr 11.
合成参考文献
参考文献:10.1021/cb9002865
摘要:Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5(2):245–53.
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