📜4-氨基-3-甲基苯甲酸甲酯置于盐酸,Copper(L) Chloride,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应生成 4-氯-3-甲基苯甲酸甲酯
参考文献:Design,Synthesis And Identification Of Novel Colchicine-Derived Immunosuppressant
标题:Design,Synthesis And Identification Of Novel Colchicine-Derived Immunosuppressant
摘要:Synthesis And Biological Evaluation Of Various Colchicine Analogues Through The Mixed-Lymphocyte Reaction (Mlr),Lymphoproliferation,And Inhibitory Effects On The Inflammatory Genes Are Described. In Addition,A New Series Of Immunosuppressive Agents Developed On The Structural Basis Of Colchicine,As Well As Their Structure-Activity Relationships Is Reported. The Most Potent Analogue 20A Exhibited An Excellent Immunosuppressive Activity On In Vivo Skin-Allograft Model,Which Is Comparable To That Of Cyclosporin A. (C) 2009 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2009.05.054