CAS: 7778-42-9; Sulfamoyl Chloride

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10438-96-7 31367-40-5 89979-13-5

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CAS号1189-71-5 氯磺酰异氰酸酯 | CAS号64-18-6 甲酸 | CAS号7732-18-5 水 | CAS号15790-84-8 Sulfamic acid,N... | CAS号19792-91-7 Phenyl sulfamate | CAS号154743-05-2 [methyl(sulfamo... | CAS号81851-30-1 butyl sulfamate | CAS号69226-51-3 2,2,2-三氯乙基氨基磺酸酯 | CAS号4403-49-0 ethyl sulfamate | CAS号55665-95-7 氨基磺酸甲酯

📜氯磺酰异氰酸酯置于甲酸体系中,用 二氯甲烷 作为反应溶剂,以80%的收率获得产物氨基磺酰氯
参考文献:通过腺苷酸化结构域的亲和探针特异性富集非核糖体肽合成酶模块
标题:通过腺苷酸化结构域的亲和探针特异性富集非核糖体肽合成酶模块
摘要:我们针对腺苷酸化(a)域的亲和力探针的开发目标,该亲和力探针可促进非核糖体肽合成酶(nrps)-聚酮化合物合酶(pks)杂种和nrpss中含有a域的模块的富集,鉴定和定量.已经报道了单磷酸腺苷(amp)的5'-O-氨磺酰腺苷(ams)不可水解类似物作为支架的支架,用于设计表现出腺苷酸化酶紧密结合的抑制剂.在这里,我们描述了针对a域的亲和探针的应用.我们的合成探针,一种生物素化的i-Phe-Ams(i-Phe-Ams-生物素)专门针对nrps模块中的a结构域,从而激活i-Phe-Ams.-在重组nrps酶系统和整个蛋白质组中均转化为氨基酰基腺苷酸中间体.
DOI:10.1016/j.Bmcl.2013.12.082

专利信息

专利号:US-2008146656-A1
优先权日:2005-06-01
标题:Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone
发明人：REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
权利人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD
摘要:There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.

专利号:US-2024368075-A1
优先权日:2021-07-02
标题 :Synthesis of N,N-Dialkyl, -Dialkenyl, -Dialkynyl, and Related Cyclics, Sulfamoyl Fluoride Compounds Using Hydrogen Fluoride
发明人：SINGH RAJENDRA P; HU QICHAO
权利人:SES HOLDINGS PTE LTD
摘要:Methods of producing N,N-dimethyl sulfamoyl fluoride and related derivatives of the formula F—S(O)2—NR2 (I) by contacting a sulfamoyl nonfluorohalide compound of the formula X—S(O)2—NR2 (II) with anhydrous hydrogen fluoride under conditions sufficient to produce the N,N-dimethyl sulfamoyl fluoride or derivative thereof of Formula I, wherein R in each of Formulas I and II is, independently, a linear or branched alkyl, alkenyl, or alkynyl group containing 1 to 12 carbon atoms, the Rs can be joined to form a cyclic amine with the N, and X is any one of chlorine, bromine, and iodine.

专利号:US-2023322661-A1
优先权日:2020-08-21
标题 :Synthesis of N,N-Branched Sulfamoyl Fluoride Compounds Using Bismuth Trifluoride
发明人：SINGH RAJENDRA P; HU QICHAO; SHEIMAN JOHNATHAN
权利人:SES HOLDINGS PTE LTD
摘要:Methods of producing N,N-branched sulfamoyl fluoride compounds of the formula F-S(O) 2 -NR 2 by contacting bismuth trifluoride with an N,N-branched sulfamoyl nonfluorohalide compound of the formula X-SO 2 NR 2 , wherein X=chlorine (Cl), bromine (Br), or iodine (I), and each R is, independently, a linear or branched alkyl, fluoroalkyl, alkenyl, fluoroalkenyl, alkynyl, or fluoroalkynyl with 1 to 12 carbon atoms, to fluorinate the N,N-branched sulfamoyl nonfluorohalide compound. This is a non-aqueous method, the purity of product is very high, and the desired product can be isolated in quantitative yield. The N,N-branched sulfamoyl fluoride compounds so produced are useful in various applications including as electrolyte solvents and additives in electrochemical devices, such as lithium batteries and capacitors, and in biological fields, among others.

专利号:US-9873688-B2
优先权日:2013-11-08
标 题:Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
发明人：TAO MING; FRIETZE WILLIAM; MELONI DAVID J; WENG LINGKAI; ZHOU JIACHENG; PAN YONGCHUN
权利人:INCYTE CORP; INCYTE HOLDINGS CORP
摘要:The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.

专利号:US-2009247618-A1
优先权日:2008-03-26
标题 :Process for preparation of benzo-fused heteroaryl derivatives
发明人：BALLENTINE SCOTT A; REANY LAURA
权利人:BALLENTINE SCOTT A; REANY LAURA
摘要:The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).