专利号:US-8450365-B2 优先权日:2009-05-12 标 题 :Efficient synthesis of galanthamine 发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ 权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS 摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.
专利号:US-2015133664-A1 优先权日:2012-06-07 标 题:Chemical transformations of (-)-codeine to afford derivatives of codeine and morphine thereof 发明人:MAGNUS PHILIP; GHAVIMI-ALAGHA BAHMAN 权利人:UNIV TEXAS 摘要:The present invention relates to methods for the synthesis of morphine, codeine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency, steroselectivity, and overall yield of said codeine and morphine related derivatives and intermediates thereof. The present invention relates to new codeine and morphine related derivative compositions.
专利号:US-7598394-B2 优先权日:2003-11-11 标题 :Process for the synthesis of imidazoles 发明人:DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E 权利人:ALLERGAN INC 摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.
专利号:US-7880017-B2 优先权日:2003-11-11 标 题 :Process for the synthesis of imidazoles 发明人:DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E 权利人:ALLERGAN INC 摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.
专利号:US-8889863-B2 优先权日:2010-07-16 标题:Stereoselective methods, catalysts and intermediates for the synthesis of (−)-Nutlin-3 and related compounds 发明人:JOHNSTON JEFFREY N; DAVIS TYLER A 权利人:JOHNSTON JEFFREY N; DAVIS TYLER A; UNIV VANDERBILT 摘要:The present invention provides methods and intermediates are provided for the preparation of (−)-Nutlin-3. Methods and intermediates are also provided for the enantioselective addition of aryl nitromethanes to aldimines. Bis(amidine) catalysts for the use in these and other reactions are also provided.
专利号:EP-1886695-A1 优先权日:2006-06-27 标 题:Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist 发明人:SCHUMACHER CHRISTOPH 权利人:SPEEDEL EXPERIMENTA AG 摘要:The invention relates to a pharmaceutical combination comprising (a) an aldosterone synthase inhibitor or a pharmaceutically acceptable salt thereof, and (b) a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a cortisol re-synthesis inhibitor or a corticotrophin-releasing hormone receptor antagonist or combinations thereof or in each case a pharmaceutically acceptable salt thereof. Said composition is useful for the manufacture of a medicament, in particular for the manufacture of a medicament for the prevention of, delay of progression of treatment of a disease or condition characterized by the metabolic syndrome.
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