CAS: 660425-07-0; 5-Chloropyridazin-3(2H)-One

相似化合物

932-22-9 17285-36-8 104566-45-2

📜4-氯-5-羟基呋喃-2(5H)-酮置于一水合肼,溶剂黄146,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应生成 5-氯哒嗪-3(2H)-酮
参考文献:Organic Compounds
标题:Organic Compounds
摘要:公式i的化合物,以自由形式,盐形式或溶剂合物形式存在,其中r1,R2和r5的含义如规范中所示,可用于治疗由alk-5和/或alk-4受体介导的疾病.还描述了含有这些化合物的药物组合物以及制备这些化合物的方法.

专利信息

专利号:WO-2024159284-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting hydrazides, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting hydrazides. More specifically, the present invention relates to hydrazides comprising formula (I):(I), in which the substituents R1 to R8 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.