CAS: 6338-41-6; 5-Hydroxymethyl-2-Furancarboxylic Acid

该化合物是一种有机化合物,其特点是它的呋喃环结构,即五人组成的含有氧气的芳香环;该化合物的特征是附于呋喃圈的氢氧甲基组(-CH2OH)和碳盒酸组(/COOH).该化合物有助于其在极地溶剂中的再活性和溶性.该产品通常是在室内温度下一种白色到光黄色的固体,在水和各种有机溶剂中可溶解.水氧甲基和碳箱酸功能组的存在使得有机合成有可能应用,特别是在制药和农用化学品开发中.此外,该化合物可能展示生物活动,使其对医药化学感兴趣.其特性,如熔点,沸点和特定再活性,可以因环境条件和其他物质的存在而不同.总体而言,5-(乙氧基甲基)-2-富氨酸在各种化学应用中具有重要潜力的多种复合化合物.

结构式图片

相似化合物

1917-60-8 36802-01-4 3238-40-2

欧盟法规

ECHA物质C&L通报

上下游产品

2,5-呋喃二甲酸 Furan-2,5-Dicarboxylic Acid 3238-40-2
5-甲醛基呋喃-2-羧酸 5-Formyl-2-Furancarboxylic Acid 13529-17-4
5-羟甲基糠醛 5-Hydroxymethyl-2-Furfuraldehyde 67-47-0
5-(羟基甲基)-2-糠酸甲酯 Methyl 5-(Hydroxymethyl)Furan-2-Carboxylate 36802-01-4
5-甲酰基-2-呋喃甲酸甲酯 Methyl 5-Formylfuran-2-Carboxylate 5904-71-2
Methyl 5-((Formyloxy)Methyl)Furan-2-Carboxylate 108153-38-4
5-[(5-羧基呋喃-2-基)甲氧基甲氧基甲基]呋喃-2-羧酸 1,5-Di(5-Carboxyfuran-2-yl)-2,4-Dioxapentan 83598-30-5
1,1-Bis-(2'-Methoxyfuroyl-5'-Methyleneoxy)Methane 36802-00-3
Methyl 5-(Acetoxymethyl)Furan-2-Carboxylate 2144-38-9
5-(Formyloxymethyl)Furfural 102390-86-3

合成工艺路线路线简述

    5-(溴甲基)呋喃-2-甲醛置于水,Silver(L) Oxide体系中,化学反应生成 5-羟甲基-2-呋喃甲酸
    参考文献:Fenton; Gostling,Journal Of The Chemical Society,1899,Vol. 75,P. 424
    标题:Fenton; Gostling,Journal Of The Chemical Society,1899,Vol. 75,P. 424

    海关参考信息

    专利信息


    专利号:US-2024368099-A1
    优先权日:2022-01-18
    标 题:Methods for the synthesis of di(hydroxymethyl)tetrahydrofuran and its application in polyesters and polyurethanes
    发明人:SPIEGELBERG BRIAN; BRANDT ADRIAN; BECK HORST; KUX ALEXANDER; TIN SERGEY; DE VRIES JOHANNES GERARDUS
    权利人:HENKEL AG & CO KGAA
    摘要:The present invention relates to the synthesis of di(hydroxymethyl)tetrahydrofuran (DHMTHF) and the preparation of trans-enriched mixtures of DHMTHF. The invention further refers to polyester polyols which are obtained by reaction of cis/trans DHMTHF mixtures with a dicarboxylic acid. The invention further relates to polyurethanes and compositions containing a polyester polyol comprising DHMTHF, in particular to such polyurethane-containing (adhesive) compositions.

    专利号:US-9359318-B2
    优先权日:2010-08-06
    标 题:Process for the synthesis of 2,5-furandicarboxylic acid
    发明人:BORSOTTI GIAMPIETRO; DIGIOIA FRANCESCA
    权利人:BORSOTTI GIAMPIETRO; DIGIOIA FRANCESCA; NOVAMONT SPA
    摘要:Process for the synthesis of 2,5-furandicarboxylic acid through the oxidation of -hydroxymethylfurfural in a flow of oxygenor a compound containing oxygen, catalyzed by a supported catalyst containing a metal of the platinum group, carried out in aqueous solution in which the pH is maintained higher than 7 and lower than 12 through the addition of a weak base.

    专利号:US-12384755-B2
    优先权日:2019-12-19
    标 题:Process for the synthesis of Furandicarboxylic acid
    发明人:RODE CHANDRASHEKHAR VASANT; DHARNE MAHESH SHANTAPPA; PARATE ROOPA DHANRAJ
    权利人:COUNCIL SCIENT IND RES
    摘要:The present invention provides a process for the synthesis of Furandicarboxylic acid (FDCA) comprising heating a mixture of fructose, aqueous NaCl or KCl, solvent, methyl isobutyl ketone (MIBK) and a catalyst at a temperature in the range of 150 to 200° C. in a sealed vessel for a time period in the range of 2 to 5 hours to yield crude 5-(hydroxymethyl)furfural (5-HMF). The crude 5-HMF further reacts with a biocatalyst at a temperature in a range of 20 to 50° C. for a period at a range of 24 to 96 hours to yield FDCA, wherein the conversion of 5-HMF to FDCA is in the range of 90 to 100%.

    专利号:US-11034986-B1
    优先权日:2017-07-25
    标 题:Comamonas testosteroni strain and use thereof for the synthesis of 5-hydroxymethyl-2-furancarboxylic acid
    发明人:LI NING; ZHANG XUEYING; ZONG MINHUA
    权利人:UNIV SOUTH CHINA TECH
    摘要:The present invention provides a Comamonas testosteroni strain and use thereof for the synthesis of 5-hydroxymethyl-2-furancarboxylic acid, wherein the strain is Comamonas testosteroni SC1588, maintained in China Center for Type Culture Collection, CCTCC for short, on Oct. 13, 2016, with an accession number of CCTCC NO: M 2016562.

    专利号:WO-2019170204-A1
    优先权日:2018-03-05
    标 题 :Synthesis of precursors of 2,5-furandicarboxylic acid
    发明人:PEDERSEN MARTIN; PEDERSEN CHRISTIAN
    权利人:UNIV COPENHAGEN
    摘要:The present invention relates to a method for the manufacture of stable FDCA precursors from saccharide derived starting materials. More specific the invention relates to the synthesis of FDCA precursors such as alkyl 5-(hydroxymethyl)furan-2-carboxylates or 5-(hydroxymethyl)furan-2-carboxylic acid in an expedient, practical and environmental benign manner from e.g. D-glucono-δ-lactone. These bio-based monomer building blocks hold great potential in the manufacture of polymer materials.

    专利号:US-11607677-B2
    优先权日:2017-10-30
    标 题:Homogeneous and reusable superacid polymer catalyst useful for the synthesis of 5-hydroxymethylfurfural from glucose
    发明人:ALBA RUBIO ANA C; COLEMAN MARIA R; KALIDINDI SUBHASH; JOSHI ANUP S; OMODOLOR IBEH S
    权利人:UNIV TOLEDO; TJIE UNIV OF TOLEDO
    摘要:A superacid polymeric catalyst having both Lewis acidity and Brønsted acidity is described, along with methods of making and methods of using the same.
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    主要参考文献

    [参考文献]: D.Jöbstl, Et Al. Analysis Of 5-Hydroxymethyl-2-Furoic Acid (Hmfa) The Main Metabolite Of Alimentary 5-Hydroxymethyl-2-Furfural (Hmf) With Hplc And Gc In Urine. Food Chemistry. 2010 Dec 1; 123 (3): 814-818.

    合成参考文献


    参考文献:10.1107/s1600536811019489
    摘要:Liu JL, Xu QY. 5-(Hy-droxy-meth-yl)furan-2-carb-oxy-lic acid. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):o1548.
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