CAS: 616204-22-9; (6S,9S,12S,15S,18S,21S)-21-Acetamido-1-Amino-12-(3-Amino-3-Oxopropyl)-6-Carbamoyl-18-(2-Carboxyethyl)-9-(3-Guanidinopropyl)-1-Imino-15-(2-(Methylthio)Ethyl)-8,11,14,17,20-Pentaoxo-2,7,10,13,16,19-Hexaazatetracosan-24-Oic Acid

上下游产品

Fm°C-Glu(OtBu)-OH acetic anhydride N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine Fm°C-L-Gln(Trt)-OH

,,,,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于碳酸氢钠,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,2-肟氰乙酸乙酯,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 0.83H,以42.16%的收率获得产物阿基瑞林
参考文献:瞬态保护基团实现的可持续肽合成.
标题:瞬态保护基团实现的可持续肽合成.
摘要:对合成肽的兴趣日益增长,促使人们开发出可持续的生产方法.当前,从受保护的结构单元组装肽需要大量有毒溶剂,并且转换为水作为反应介质仍然是肽化学中的主要障碍.我们报告了一种基于水相容性2,7-二硫代-9-芴基甲氧基羰基(smoc)保护基的固相肽水合成策略.这种方法可在水性条件下进行肽组装,实时监测构件偶联以及有效的合成后纯化.描述了合成所有天然和几种非天然smoc保护的氨基酸的程序,以及22种肽序列的组装和spps的基本问题,
DOI:10.1002/anie.202003676

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:WO-2024222981-A1
优先权日:2023-04-28
标题 :Ester conjugate of sphingolipid and hyaluronan, method of synthesis thereof, composition containing thereof, use of conjugate or composition
发明人：JUHASCIK MARTIN; HUERTA-ANGELES GLORIA; STARMANOVA KATERINA; STEPAN PETR; EXNEROVA ANDREA; NESPOROVA KRISTINA; KOVACIK ANDREJ; BRANDEJSOVA MARTINA; VECEROVA PETRA; POLASKOVA JANA; HERMANNOVA MARTINA; BUFFA RADOVAN; VAGNEROVA HANA; VELEBNY VLADIMIR
权利人:CONTIPRO AS
摘要:The present invention relates to an ester conjugate of sphingolipid and hyaluronan, a composition comprising thereof and its use. Furthermore, it relates to methods of the ester conjugate synthesis.

专利号:US-12161745-B2
优先权日:2019-03-28
标题:Peptides and compositions for use in cosmetics
发明人：GRAU-CAMPISTANY ARIADNA; PASTOR SILVIA; CARULLA PATRICIA; ESCUDERO JUAN CARLOS; BORAS JULIA A; KLEIN MARCO JAN
权利人:LIPOTRUE S L
摘要:A family of peptides which are able to increase synthesis of homeodomain protein Mohawk and useful as anti-aging agents and as rejuvenating agents.

专利号:US-2015329593-A1
优先权日:2014-05-19
标题:Synthesis of Beta-Arrestin Effectors

专利号:US-9125843-B2
优先权日:2013-10-03
标 题 :Methods and compositions for improving the appearance of skin
发明人：PERNODET NADINE A; COLLINS DONALD F
权利人:PERNODET NADINE A; COLLINS DONALD F; ELC MAN LLC
摘要:A method for stimulating collagen synthesis in aging skin cells in need of treatment by topically applying a composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus, and at least one peptide that stimulates sirtuin 6 activity in the form of a peptide or a yeast extract where the peptide is component of the extract; and a treatment composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus; and at least one peptide that stimulates sirtuin 6 activity.

专利号:CN-114057838-A
优先权日:2022-01-11
标 题 :Solid Phase Synthesis of Acetyl Hexapeptide-8