CAS: 59752-57-7; (2R)-3-(((2-Aminoethoxy)(Hydroxy)Phosphoryl)Oxy)Propane-1,2-Diyl Didodecanoate

上下游产品

Dioleoyl Phosphatidylethanolamine 20707-71-5
1,2-二月桂酰-Sn-甘油 Dodecanoic Acid 1,1'-[(1S)-1-(Hydroxymethyl)-1,2-Ethanediyl]Ester 17598-94-6

📜在 1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.5H,以88%的收率获得产物1,2-二月桂酰磷脂酰乙醇胺
参考文献:一种二酰基磷脂酰乙醇胺的制备方法
标题:一种二酰基磷脂酰乙醇胺的制备方法
摘要:本发明提供了一种二酰基磷脂酰乙醇胺的制备方法,包括下列步骤:(1)溶剂和有机碱/无机碱的作用下,式i化合物和磷试剂发生取代反应,反应生成式a中间体1;(2)同一反应体系中,中间体1在有机碱/无机碱的存在下,与2‑(N‑芴甲氧羰基氨基)乙醇或n‑boc保护的乙醇胺发生取代反应,反应生成式b中间体2;(3)同一反应体系中,中间体2在氧化剂作用下氧化反应,反应生成式ii化合物;(4)式ii化合物在溶剂,碱的作用下,磷脂头基发生水解,得到式iii化合物.本发明的优点在于:本发明只需通过两步合成就可得到目标产物,且方法条件易控,后处理简单,副反应少,收率高,符合工业化生产的要求.

专利信息

专利号:US-12247239-B2
优先权日:2019-06-21
标题:Chemo-enzymatic process for the preparation of homopropargylic alcohol
发明人：CHANDRASEKHAR SRIVARI; GHOSH SUBHASH; KRISHNA AVULA SHIVA; REDDY CHADA RAJI; SUDHAKAR GANGARAJULA; THENKRISHNAN KUMARAGURU; PABBARAJA SRIHARI; MAINKAR PRATHAMA SATYENDRA; NASAM RAJESH
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人：SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

专利号:US-10730899-B2
优先权日:2013-06-14
标 题 :Lipid-based platinum compounds and nanoparticles
发明人：SENGUPTA SHILADITYA; ROY MONIDEEPA; SARKAR ARINDAM; HOSSAIN SK SAMAD; SENGUPTA ANIRUDDHA; DUTTA PRADIP; ANSARI AASIF
权利人:AKAMARA THERAPEUTICS INC
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

专利号:US-2025281557-A1
优先权日:2024-03-08
标 题:Methods for cascade amplifications of therapeutic payloads (catp) & compositions for cancer immunotherapies and gene therapy
发明人：LI YINGZHONG; ZHANG LIBIN
权利人:SUNVAX MRNA THERAPEUTICS INC
摘要:The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncolytic defective virus compositions and methods of in vivo synthesis thereof. The composition includes a first nucleic acid construct encoding a self-amplifying mRNA (sa-mRNA) encoding at least one gene of interest (GOI) or a plurality of GOIs, a second nucleic acid construct encoding an mRNA encoding at least one virus structural protein, and at least one payload delivery system.

专利号:AU-2005200425-A1
优先权日:2000-05-30
标题 :A method for the synthesis of compounds of formula 1 and their uses thereof

专利号:WO-9817695-A1
优先权日:1993-12-15
标 题 :Compounds and methods
发明人：CHENERA BALAN
权利人:SMITHKLINE BEECHAM CORP; CHENERA BALAN
摘要:This invention also relates to novel silicon-based polymer resins and silane linkers, methods for their preparation and their use in the synthesis of libraries of compounds to be screened as pharmaceutical agents.