CAS: 5328-63-2; Methyl β-D-Arabinopyranoside

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L-arabinose L-arabinose dibenzyl dithioacetal methanol L-(+)-arabinoseO-benzoyl-β-D-arabinopyranoside)methyl-(tri-O-benzoyl-β-D-arabinopyranoside) O-methanesulfonyl-β-D-arabinopyranoside)methyl-(tris-O-methanesulfonyl-β-D-arabinopyranoside) methyl 3,4-O-isopropylidene-β-D-arabinopyranoside O1,O2;O3,O4-diisopropylidene-β-D-arabinopyranoseO1,O2;O3,O4-diisopropylidene-β-D-arabinopyranose

📜D-吡喃木糖置于sodium Tetrahydroborate,四氧化锇,Cerium(Iii) Chloride,四氯化锡,N-甲基吗啉氧化物体系中,用 吡啶,甲醇,二氯甲烷,水,溶剂黄146,1,2-二氯乙烷,叔丁醇 作为反应溶剂,化学反应 25.83H,反应生成 甲基β-D-阿拉伯吡喃糖苷
参考文献:旋光的2-烷氧基-2H-吡喃-3(6H)-酮的合成.它们在diels-Alder环加成中用作亲双烯体.
标题:旋光的2-烷氧基-2H-吡喃-3(6H)-酮的合成.它们在diels-Alder环加成中用作亲双烯体.
摘要:通过氯化锡(iv)促进的糖基化和2-乙酰氧基-3,4-二-的重排,一步合成了光学活性的2-烷氧基-2H-吡喃-3(6H)-一(4A-D).由d-木糖(1)制备的o-乙酰基-D-木糖醛(3).通过将二氢吡喃酮4A和4B化学转化为已知的烷基戊吡喃糖苷(分别为7A和7B)来确定c-2处新立体中心的绝对构型.同样,从使用手性位移试剂的(1)h NMR实验中,确定了4A(> 86%)和4B(> 77%)的对映体过量.通过3与手性2-辛醇(分别为r和s)反应获得对映体纯的4C和4D.二氢吡喃酮4A-D在与2,3-二甲基丁二烯和丁二烯的diels-Alder环加成中用作亲二烯体.在热条件下 仅以非常好的非对面选择性(＞ 80%)分别获得中等产率(约50%)的环加合物9A-C和10A.优化的路易斯酸促进的环加成反应导致9A-D和10A,C的产率更高(约80%),非对映选择性更高(> 94%).主要产物是由二
DOI:10.1021/jo0106896

专利信息

专利号:US-9512162-B2
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9493773-B2
优先权日:2012-07-31
标题:Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9365607-B1
优先权日:2012-07-31
标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-9045521-B2
优先权日:2012-07-31
标 题 :Synthesis of deuterated ribo nucleosides N-protected phosphoramidites, and oligonucleotides
发明人：SRIVASTAVA SURESH C; YASKO AMY
权利人:SRIVASTAVA SURESH C; YASKO AMY; ASED LLC
摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.

专利号:US-2014039175-A1
优先权日:2012-07-31
标 题:Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides

专利号:JP-6799918-B2
优先权日:2012-07-31
标题 :Synthesis of deuterated ribonucleosides, N-protected phosphoramidite, and oligonucleotides