CAS: 508-59-8; Parthenin

📜3-Dimethylamino-2-((3Ar,4R,5S)-4-Hydroxy-3A,8-Dimethyl-3-Oxo-3,3A,4,5,6,7-Hexahydro-Azulen-5-yl)-N,N-Dimethyl-Propionamide置于silica Gel体系中,用 乙酸乙酯 作为反应溶剂,以15 Mg的收率获得产物银胶菊宁
参考文献:Bhat,Uppoor G.; Kulkarni,Mandakini M.; Rojatkar,Supada R.,Indian Journal Of Chemistry,Section B: Organic Chemistry Including Medicinal Chemistry,1989,Vol. 28,P. 543-546
标题:Bhat,Uppoor G.; Kulkarni,Mandakini M.; Rojatkar,Supada R.,Indian Journal Of Chemistry,Section B: Organic Chemistry Including Medicinal Chemistry,1989,Vol. 28,P. 543-546

专利信息

专利号:US-6528646-B2
优先权日:1998-01-30
标题 :Intermediates for the synthesis of debromohymenialdisine and process thereof
发明人：HORNE DAVID A; YAKUSHIJIN KENICHI
权利人:UNIV COLUMBIA
摘要:The synthesis of C 11 N 5 marine sponge alkaloids (±)-hymenin (1), stevensine (2), hymenialdisine (3), and debromohymenialdisine (4) is described. These natural products are the primary family members of the sponge metabolites that contain a fused pyrrolo[2,3-c]lazepin-8-one ring system with either a 2-aminoimidazole (AI) or glycocyamidine appendage. The key steps in the synthesis centered around the generation of novel azafulvenium ions and their regioselective heterodimerization with AI in order to create the tricyclic core. A rarely used protodebromination/oxidation strategy was employed to selectively generate the desired a-bromo substitution pattern seen in hymenialdisine (3). In addition, the AI moiety was shown to be a useful precursor to the glycocyamidine unit found in 3 and 4, which suggests that AI derived natural products may be the biogenic forerunners to glycocyamidine metabolites.

专利号:US-2001012891-A1
优先权日:1998-01-30
标 题 :Intermediates for the synthesis of debromohymenialdisine and process thereof

专利号:US-6197954-B1
优先权日:1998-01-30
标题:Intermediates for the synthesis of debromohymenialdisine and processes thereof

专利号:EP-0693072-B9
优先权日:1993-04-08
标题 :Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes

专利号:EP-0693072-A4
优先权日:1993-04-08
标 题 :PROCESS FOR THE SYNTHESIS OF 2-AMINOIMIDAZOLES (BI) SUBSTITUTED IN POSITION 4 and / or 5 FROM 2-AMINOIMIDAZOLES AND ALDEHYDES

专利号:WO-9424136-A1
优先权日:1993-04-08
标题 :Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes