CAS: 498-95-3; Piperidine-3-Carboxylic Acid

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59045-82-8 163438-09-3 193693-67-3

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CAS号59-67-6 烟酸 | CAS号584-08-7 碳酸钾 | CAS号71962-74-8 呱啶乙酯 | CAS号110-89-4 六氢吡啶 | CAS号64-18-6 甲酸 | CAS号89-00-9 吡啶-2,3-二羧酸 | CAS号50585-89-2 3-哌啶甲酸甲酯 | CAS号7732-18-5 水 | CAS号35090-94-9 (3-哌啶基)(1-吡咯烷基)甲酮 | CAS号5657-70-5 1-甲基哌啶-3-羧酸 | CAS号4842-86-8 3-哌啶甲酸乙酯盐酸盐 | CAS号174543-74-9 N-Cbz-3-哌啶甲酸甲酯 | CAS号50585-89-2 3-哌啶甲酸甲酯 | CAS号174543-78-3 1-Cbz-3-甲基哌啶-3-甲酸 | CAS号2637-75-4 3-Piperidinecar... | CAS号88466-74-4 (S)-1-((苄氧基)羰基)... | CAS号832739-59-0 1-[(3-氯苯基)甲基]-3-哌啶甲酸 | CAS号89895-55-6 3-哌啶甲酸甲酯盐酸盐

在 水,三乙胺体系中,用 四氢呋喃,正戊烷 作为反应溶剂,化学反应 4.0H,反应生成 3-哌啶甲酸
参考文献:未保护β2-氨基酸的催化不对称合成
标题:未保护β2-氨基酸的催化不对称合成
摘要:我们在这里报告了一种可扩展的催化一锅法,用于对映体纯和未修饰的 β 2-氨基酸.新开发的密闭imidodiphosphorimidate(idpi)催化各种的广泛适用的反应双甲硅烷基烯酮缩醛与甲硅烷基化氨基甲基醚,接着通过水解后处理,得到游离β 2个以高收率,纯度,和对映选择性α-氨基酸.重要的是,使用这种方法可以获得芳香族和脂肪族 β 2氨基酸.机理研究与通过基于甲硅烷基的不对称反阴离子导向催化 (Si-Acdc) 进行的氨甲基化一致,并在密度泛函理论计算的基础上提出了解释对映选择性的过渡态.
DOI:10.1021/jacs.1C00249

专利信息

专利号:US-5220016-A
优先权日:1991-07-29
标 题:Synthesis of navelbine analogs
发明人：MAGNUS PHILIP D; THURSTON LEE S
权利人:UNIV TEXAS
摘要:The invention is a de novo synthesis of the norcatharanthine moiety of navelbine. The synthesis includes condensing a Grignard reagent prepared from an amine-protected R(+)-piperidinyl methanol with an N-protected 2-methoxyoxalyl indole. The indole N-protecting group is removed to provide a 2-methoxyindole hydroxy ester which is coupled to vindoline. After removal of the amineprotecting group from the piperidinyl group, ring closure to the indole moiety provides dihydrodesethyl navelbine. Other derivatives and analogs of navelbine with potential clinical applications in cancer chemotherapy may be readily synthesized. The synthesis opens a route to a wide variety of navelbine modifications, including modifications at or near the tryptamine bridge.

专利号:US-9957355-B2
优先权日:2013-06-12
标 题 :Device and method for synthesis of a polymer under separation of a gaseous substance
发明人：ZHU NING; STAMMER ACHIM; CLAUSS JOACHIM; KORY GAD
权利人:BASF SE
摘要:The invention relates to a device for synthesis of a polymer under separation of a gaseous substance. Said device comprises a reaction chamber ( 1 ), which has a top section ( 11 ), a middle section ( 12 ) and a bottom section ( 13 ), an inlet opening ( 2 ) which is arranged in the middle section ( 12 ), a first outlet opening ( 3 ) which is arranged in the bottom section ( 13 ), a second outlet opening ( 4 ) which is arranged in the top section ( 11 ), a first return opening ( 51 ), which is arranged in the bottom section ( 13 ), a second outlet opening ( 52 ), which is arranged under the top section ( 11 ), a distribution device ( 6 ), which is arranged between the top section ( 11 ) and the middle section ( 12 ), and a removal device ( 7 ) which is arranged to be movable along the top section ( 11 ). The invention further relates to a method for synthesis of a polymer which can be carried out in said device.

专利号:US-7423169-B2
优先权日:2001-06-11
标 题:Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
发明人：RAILLARD STEPHEN P; ZHOU CINDY X; YAO FENMEI; MANTHATI SURESH KUMAR; XIANG JIA-NING; GALLOP MARK A
权利人:XENOPORT INC
摘要:The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-8158817-B2
优先权日:2003-12-24
标 题 :Synthesis of acylureas and composition comprising acylureas
发明人：BERNARD JEAN-MARIE; REVELANT DENIS; AMOUYAL CEDRIC
权利人:BERNARD JEAN-MARIE; REVELANT DENIS; AMOUYAL CEDRIC; PERSTORP FRANCE
摘要:The invention relates to a process for the synthesis of a polyisocyanate composition comprising acylureas. According to the invention, a starting composition comprising a compound having at least two isocyanate functional groups is subjected to a reaction with at least two acid functional groups, with at least one of the acid functional groups having a pKa value of less than or equal to 3, and at least one of the acid functional groups having a pKa value of more than 3 and less than or equal to 6, at a temperature at least equal to 50 ° C., wherein the acid functional group having a pKa value of less than or equal to 3 and the acid functional group having a pKa value of more than 3 and less than or equal to 6 are present on two different acids or on the same acid.

专利号:US-4400550-A
优先权日:1982-02-12
标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
发明人：BISHOP CLYDE E; MORROW GARY W
权利人:ALBANY INT CORP
摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.