CAS: 395-44-8; 1-(Bromomethyl)-2-(Trifluoromethyl)Benzene

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CAS号346-06-5 邻三氟甲基苯甲醇 | CAS号433-97-6 邻三氟甲基苯甲酸 | CAS号3796-19-8 2-trifluorometh... | CAS号395-47-1 (2-(trifluorome... | CAS号447-61-0 邻三氟甲基苯甲醛 | CAS号3048-01-9 2-(三氟甲基)苄胺 | CAS号3038-47-9 邻三氟甲基苯乙腈 | CAS号3038-48-0 2-三氟甲基苯乙酸 | CAS号712-20-9 N,N-Dimethyl-1-... | CAS号823189-03-3 1-(azidomethyl)...

邻三氟甲基苯甲醛置于dipotassium Peroxodisulfate,Tris(2,2'-Bipyridyl)Dichlororuthenium(II) Hexahydrate,四丁基硫酸氢铵,Sodium Bromide体系中,用 水,乙二醇,乙腈 用作溶剂,化学反应 28.0H,反应生成2-(三氟甲基)苄溴
参考文献:通过脱甲酰卤化从醛合成烷基卤化物.
标题:通过脱甲酰卤化从醛合成烷基卤化物.
摘要:提出了一种前所未有的醛去酰卤化为烷基卤化物的方法.在氧化条件下,衍生自醛的 1,4-二氢吡啶 (Dhp) 反应生成C(Sp3)-自由基,该自由基与廉价且原子经济的卤素源(nabr,Nai 或 Hcl)生成的卤素自由基偶联. ),得到卤代烷.由于条件温和,可以耐受多种官能团,并且实现了优异的位点选择性.
Doi:10.1021/acs.Orglett.9B01337

专利信息

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:US-2009118296-A1
优先权日:2005-07-20
标 题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
发明人：BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.

专利号:US-2009099200-A1
优先权日:2005-06-09
标题 :Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
权利人:LI CHUN SING; RAMTOHUL YEEMAN K; HUANG ZHENG; LACHANCE NICOLAS
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2009170828-A1
优先权日:2006-06-12
标题:Azetidine Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
权利人:ISABEL ELISE; OBALLA RENATA; POWELL DAVID; ROBICHAUD JOEL
摘要:Azetidine derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis. (I)

专利号:US-2009291955-A1
优先权日:2005-11-15
标题 :Azacyclohexane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：CRANE SHELDON N; ROBICHAUD JOEL STEPHANE; LEGER SERGE; RAMTOHUL YEEMAN K
权利人:CRANE SHELDON N; ROBICHAUD JOEL STEPHANE; LEGER SERGE; RAMTOHUL YEEMAN K
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.