CAS: 33605-76-4; For-Asp-Phe-Ome

上下游产品

CAS号116147-62-7 n-formyl-l-aspa... | CAS号7524-50-7 L-苯丙氨酸甲酯盐酸盐 | CAS号100101-47-1 (Z)-N-(N-formyl... | CAS号19427-28-2 N-甲酰-L-天冬氨酸 | CAS号2577-90-4 (S)-2-氨基-3-苯基丙酸甲酯 | CAS号33605-73-1 (S)-(-)-2-甲酰胺琥珀酸酐 | CAS号22839-47-0 阿斯巴甜

📜L-苯丙氨酸甲酯盐酸盐 反应生成 N-甲酰基-L-天冬氨酰-L-苯丙氨酸甲酯
参考文献:Kato,Tosio;Xiguti,Tedziro;Oura,Takehsi;Adzioka,Masanobu;Yamaguti,Aki+
标题:Kato,Tosio;Xiguti,Tedziro;Oura,Takehsi;Adzioka,Masanobu;Yamaguti,Aki+

专利信息

专利号:WO-0037486-A1
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO; QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-α-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-α- and β-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:US-6617127-B2
优先权日:1998-12-22
标题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER J L M; SONKE THEODORUS; WAGNER ADOLF F V
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl-alpha-L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl-alpha- and beta-L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:EP-1140982-B1
优先权日:1998-12-22
标 题:Synthesis and recovery of aspartame involving enzymatic deformylation step
发明人：QUAEDFLIEG PETER JAN LEONARD M; SONKE THEODORUS; WAGNER ADOLF FRITZ VOLKER
权利人:HOLLAND SWEETENER CO
摘要:The invention relates to the synthesis of aspartame involving enzymatic deformylation of an N-formyl- alpha -L-aspartyl-L-phenylalanine compound by treatment with an enzyme having formylmethionyl peptide deformylase activity and having as a co-factor group 5 to 11 bivalent metal ions. The invention also relates to selective preparation and recovery of aspartame from a mixture of N-formyl- alpha - and beta -L-aspartyl-L-phenylalanine compounds by treatment with such enzyme. And finally, the invention relates to one-pot enzymatic synthesis of aspartame from N-formyl-L-aspartic acid and L- or D,L-phenylalanine methyl ester involving an enzymatic deformylation reaction simultaneously with an enzymatic coupling reaction, as well as to one-pot di- or oligopeptide synthesis by simultaneous enzymatic coupling and deformylation reactions in general.

专利号:JP-H10174597-A
优先权日:1996-10-15
标题:Enzymatic synthesis of n-formyl-alpha-l-aspartyl-l-phenylalanine methyl ester

专利号:DE-3786403-T2
优先权日:1986-09-04
标 题 :Process for the synthesis of N-formyl-aspartyl-phenylalanine and its methyl ester.

专利号:US-4549987-A
优先权日:1983-08-12
标题:Aspartame synthesis
发明人：DALLATOMASINA FRANCO; ORTICA ROBERTO; GIARDINO PIETRO; OPPICI ERNESTO
权利人:ERBA FARMITALIA
摘要:A process for deformylation and separation of N-formyl-L- α-aspartyl-L-phenylalanine methyl ester from a mixture containing both α and β isomers thereof, which comprises admixing with said isomeric mixture hydrogen peroxide and an organic acid.