CAS: 328-42-7; Oxalacetic Acid

相似化合物

108-56-5 636-61-3 6915-15-7

上下游产品

CAS号142-45-0 丁炔二酸 | CAS号636-61-3 D-(+)-苹果酸 | CAS号765-87-7 1,2-环己二酮 | CAS号97-67-6 L-苹果酸 | CAS号617-48-1 DL-苹果酸 | CAS号617-45-8 DL-天门冬氨酸 | CAS号77287-34-4 甲亚胺酸 | CAS号124-38-9 二氧化碳 | CAS号127-17-3 丙酮酸 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号3952-66-7 2-氧代丁酸甲酯 | CAS号513-86-0 3-羟基-2-丁酮 | CAS号97-67-6 L-苹果酸 | CAS号75-07-0 乙醛 | CAS号513-85-9 2,3-丁二醇 | CAS号19064-79-0 3-Acetyloxy-2,5... | CAS号1783-96-6 D-天门冬氨酸 | CAS号127-17-3 丙酮酸 | CAS号124-38-9 二氧化碳

L-苹果酸置于β-烟酰胺腺嘌呤二核苷酸 Sodium Hydroxide,聚甘氨酸体系中,用 水 作为反应溶剂,化学反应生成 草酰乙酸
参考文献:Purification,Characterization,And Overexpression Of Psychrophilic And Thermolabile Malate Dehydrogenase Of A Novel Antarctic Psychrotolerant,Flavobacterium Frigidimariskuc-1
标题:Purification,Characterization,And Overexpression Of Psychrophilic And Thermolabile Malate Dehydrogenase Of A Novel Antarctic Psychrotolerant,Flavobacterium Frigidimariskuc-1
摘要:我们从南极海水中分离出的一种新型心理耐受性黄杆菌(flavobacterium Frigidimaris Kuc-1)中纯化出了具有心理亲和性和热稳定性的苹果酸脱氢酶.该酶是一种同源四聚体,分子量约为 123 K,亚基分子量约为 32 K.该酶需要 Nad(P)+ 作为辅酶,专门催化 L-苹果酸的氧化和草酰乙酸的还原.反应通过有序的双生物机制进行.该酶极易受热处理影响,在 40 oc 时的半衰期估计为 3.0 分钟.30 oc时,L-苹果酸和nad+的kcat/km(μm-1-S-1)值分别为289和2,790.该酶对辅酶烟酰胺分子 C4 位的氢转移具有亲 R 立体特异性.该酶含有 311 个氨基酸残基,脯氨酸和精氨酸残基的数量远低于其他苹果酸脱氢酶.
DOI:10.1271/bbb.69.2146

专利信息

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:WO-9216541-A1
优先权日:1991-03-12
标 题 :Synthesis of sialic acid and synthetic intermediate therefor
发明人：SHIBA TETSUO; TESHIMA TADASHI; YAMAMOTO TOSHIHIRO
权利人:KANTO ISHI PHARMA CO LTD
摘要:An efficient synthesis of sialic acid (N-acetylneuramic acid) useful as the starting material of medicines, a synthetic intermediate therefor, isosialic acid as an isomer of sialic acid, synthesis thereof, and a synthetic intermediate therefor. Sialic acid is synthesized from D-glucose and oxaloacetic acid through the intermediates (Ia) and (IIIa), while isosialic acid represented by formula (IV) is synthesized from an isomer of the intermediate (Ia).

专利号:US-6579725-B1
优先权日:1999-03-05
标题 :Linkers for synthesis of oligosaccharides on solid supports
发明人：SEEBERGER PETER H; ANDRADE RODRIGO B
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention relates to versatile linkers for tethering a molecule to a solid support, e.g., for tethering a monomer, oligomer or polymer to a solid support, which are stable to a wide range of reaction conditions, but can be cleaved under well-defined conditions, thereby liberating the molecule from the solid support. Preferably, the linkers are used to tether to the solid support unprotected, partially-protected or fully-protected monosaccharides or oligosaccharides, or unprotected, partially-protected or fully-protected glycoconjugates. The linkers of the present invention may be used to tether to solid supports building blocks useful in the assembly of libraries of other types of small molecules. The present invention also relates to a molecule or plurality of molecules tethered to the solid support via a linker or linkers of the present invention. The present invention also relates to processes for synthesizing molecules, e.g., monomers, oligomers or polymers, on a solid support, wherein a starting material in the synthesis of the molecule, intermediates in the synthesis of the molecule, and the molecule itself are tethered to the solid support during the process via one of the linkers of the present invention. In certain processes of the present invention, the molecule is liberated from the solid support by cleavage of the linker of the present invention.

专利号:US-8252928-B2
优先权日:2008-09-16
标题:Processes for the synthesis of five and six membered heterocyclic rings
发明人：WANG PETER X; JIANG TAO; BERBERICH DAVID W
权利人:WANG PETER X; JIANG TAO; BERBERICH DAVID W; MALLINCKRODT LLC
摘要:The present invention provides processes for the synthesis of five and six membered rings. In particular, the present invention provides processes for the synthesis of five and six membered rings in alkaloids.

专利号:US-6994986-B2
优先权日:1999-03-17
标 题:In vitro synthesis of polypeptides by optimizing amino acid metabolism
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides. In order to improve the performance of in vitro protein synthesis reactions, metabolic inhibitors, or manipulation of a source organism, is used to diminish or avoid the action of enzymes responsible for undesirable amino acids production or depletion. A homeostatic system may be used for production of ATP, where the required high energy phosphate bonds are generated in situ, e.g. through coupling with an oxidation reaction. The homeostatic energy source will typically lack high energy phosphate bonds itself, and will therefore utilize free phosphate in the reaction mix during generation of ATP. The homeostatic energy source is provided in combination with an enzyme that catalyzes the creation of high energy phosphate bonds and with an enzyme that can use that high energy phosphate bond to regenerate ATP.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.