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专利信息
专利号:WO-2007069266-A3
优先权日:2005-12-12
标题 :A novel process for the synthesis of bisodprolol and its intermediate
发明人:RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
权利人:UNICHEM LAB LTD; RAMAKRISHNAN ARUL; AJAY DAYALJI CHAUHAN; RAJESH HARSHNATH PATHAK; RUCHI AGARWAL
摘要:This invention relates to a manufacturing process for the preparation of bisoprolol and its pharmaceutically acceptable salt as well as its intermediates. The intermediate 4-[(2-isopropoxyethoxy)methyl]phenol is prepared by reaction of 4-hydroxybenzyl alcohol with 2-isopropoxy ethanol in presence of Amberlyst 15 in high yield with high purity.
专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:WO-2007069266-A2
优先权日:2005-12-12
标 题 :A novel process for the synthesis of bisodprolol and its intermediate
专利号:CN-102746169-A
优先权日:2012-07-27
标 题 :Synthesis of metoprolol impurity C
专利号:CN-104177267-A
优先权日:2014-04-28
标题 :A kind of N-isopropyl-2-hydroxyl-3-p-formaldehyde phenoxypropylamine oxalate and its synthesis method