CAS: 28342-75-8; 1,5-Dibromo-2,4-Difluorobenzene

上下游产品

CAS号348-57-2 2,4-二氟溴苯 | CAS号679836-60-3 1,5-Dibromo-2,4... | CAS号864773-64-8 1-(5-溴-2,4-二氟苯基)乙酮 | CAS号355423-48-2 5-溴-2,4-二氟苯酚 | CAS号473416-91-0 5-溴-2,4-二氟苯甲醛

1,5-二溴-2,4-二氟-3-碘苯置于丙烷-1-硫醇,Sodium Hydride体系中,用 二甲基亚砜 用作溶剂,化学反应 48.0H,反应生成1,5-二溴-2,4-二氟苯
参考文献:1,3-二氟-2,4,6-三卤代苯胺和苯的合成和硫醇化
标题:1,3-二氟-2,4,6-三卤代苯胺和苯的合成和硫醇化
摘要:通过逐步卤化3,5-二氟苯胺制备三种五卤代苯胺,并将其脱氨基形成五卤代苯.或者,通过锂化然后将1,3-二氟-4,6-二卤代苯碘化而获得两个五卤代苯.研究了me 2 So中五卤代苯胺和苯的烷基硫醇化反应.
Doi:10.1016/s0022-1139(03)00172-6

专利信息

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-9198917-B2
优先权日:2012-12-11
标题:Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; DAVOREN JENNIFER ELIZABETH; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure n nwherein the variables R 1 , R 2 , R 3 , R 4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.