专利号:US-8030496-B2 优先权日:2005-02-17 标 题:Intermediate compound for synthesis of viridiofungin a derivative 发明人:KATO TATSUYA; KIMURA NOBUAKI; MIZUTANI AKEMI; MAKINO TOSHIHIKO; KAWASAKI KENICHI; FUKUDA HIROSHI; KOMIYAMA SUSUMU; TSUKUDA TAKUO 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:A method whereby a compound having HCV replication inhibitory activity and desired optical activity can be synthesized selectively and at high yield in a small number of steps by using a compound having a specific chiral auxiliary as a starting compound is provided. n A compound represented by the formula (1-8): n n n n n n n n n n n n wherein Y represents a group represented by the following formula: n n n n n n n n n n n n n n n n Q represents a protected carbonyl group; D represents —(CH 2 ) m —R′, etc.; and n represents an integer of 0 to 10.
专利号:US-7897783-B2 优先权日:2005-02-17 标题 :Intermediate compound for synthesis of viridiofungin a derivative
专利号:US-4073795-A 优先权日:1976-06-22 标 题:Synthesis of tryptophans
专利号:US-2010152456-A1 优先权日:2005-02-17 标题 :Intermediate compound for synthesis of viridiofungin a derivative
专利号:US-2010152457-A1 优先权日:2005-02-17 标 题 :Intermediate compound for synthesis of viridiofungin a derivative
专利号:US-2008176857-A1 优先权日:2005-03-25 标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
参考标题:Synthesis Of The New Types Of N-Substituted Aminomethylenebisorganophosphorus Acids And Their Derivatives 作者:Andrey A. Prishchenko,Mikhail V. Livantsov,Olga P. Novikova,Ludmila I. Livantsova,Valery S. Petrosyan 摘要:Trivalent Organophosphorus Acids Containing Ph And Posime3 Fragments With Various Derivatives Of Formamide Is Proposed As Convenient Methods For The Synthesis Of New N-Substituted Aminomethylenebisorganophosphorus Acids And Their Derivatives With Three-, Four-, And Five-Coordinated Phosphorus. Also The New Functionalized Derivatives Of The New Aminomethylenebisphosphinic Acids With Substituted Hydroxymethyl
合成参考文献
参考文献:10.1055/s-2008-1077882 摘要:Vorbrüggen H. Esterification of Carboxylic Acids and Etherification of Phenols with Amide Acetals. Synlett. 2008 Jun 20;2008(11):1603–17. doi: 10.1055/s-2008-1077882.