专利号:US-9981239-B2 优先权日:2015-04-21 标题:Devices and methods for oligonucleic acid library synthesis 发明人:BANYAI WILLIAM; PECK BILL JAMES; FERNANDEZ ANDRES; CHEN SIYUAN; INDERMUHLE PIERRE; MARSH EUGENE P 权利人:TWIST BIOSCIENCE CORP 摘要:Devices and methods for de novo synthesis of large and highly accurate libraries of oligonucleic acids are provided herein. Devices include structures having a main channel and microchannels, where the microchannels have a high surface area to volume ratio. Devices disclosed herein provide for de novo synthesis of oligonucleic acids having a low error rate.
专利号:US-2024010511-A1 优先权日:2019-05-02 标 题 :Methods and compositions for synthesis of phosphor and its incorporation in a polymer matrix for light conversion 发明人:SAHI SUNIL 权利人:SOLGO INC; SOLGRO INC 摘要:The invention relates to methods and compositions for synthesizing a phosphor and preparing a surface-modified phosphor comprising a phosphor, a silica, and a silane, and articles comprising same. The invention also relates to a method of dispersion of the disclosed surface-modified phosphor with a blue emitting agent in a polymer matrix and uses thereof.
专利号:WO-2023196499-A1 优先权日:2022-04-07 标 题:Substrate cleavage for nucleic acid synthesis 发明人:LACKEY JEREMY; DODD DAVID; LANGNER HEERA 权利人:TWIST BIOSCIENCE CORP 摘要:Disclosed herein are methods and compositions for cleavage of nucleic acids from a surface of a solid support. Further described herein are cleavage methods compatible with enzymatic and chemical nucleic acid synthesis methods.
专利号:US-2018104664-A1 优先权日:2016-08-03 标 题 :Textured surfaces for polynucleotide synthesis 发明人:FERNANDEZ ANDRES; INDERMUHLE PIERRE; MARSH EUGENE P; BANYAI WILLIAM; PECK BILL JAMES 权利人:TWIST BIOSCIENCE CORP 摘要:Methods, devices and systems are provided herein for surfaces for de novo polynucleotide synthesis that provide for increased polynucleotide yield. Surfaces described herein comprise a texture that increases surface area provide for increased polynucleotide yield compared to non-textured surfaces. In addition, the patterned placement of nucleoside coupling reagent spanning such surfaces provides for improved synthesis yield, representation, and a reduction in contamination on the surface between different polynucleotide species.
专利号:US-2022355262-A1 优先权日:2019-07-22 标题 :System and method for manufacturing water-based hydrophobic aerogels and aerogel composites 发明人:SACHITHANADAM MAHESH; KHORASGANI SOGHRATI ELMIRA; NATARAJAN GAYATHRI 权利人:KROSSLINKER PTE LTD 摘要:Embodiments of the present invention provide users with a system and method for manufacturing water-based hydrophobic aerogels and aerogel composites. The system and method can be carried out in a manner which is more rapid than typical ways and can be readily scalable. The method of manufacture is useful for producing water based hydrophobic aerogels and aerogel composites on a large scale with good homogeneity and consistency. Advantageously, the method of manufacture also has the benefit of a shorter processing time due to the vacuum homogenizing and mixing processes, the use of microwave assisted vacuum freeze drying for ease of synthesis of water-based hydrophobic aerogels.
专利号:US-6177534-B1 优先权日:1997-12-23 标题 :Silylated resins and the synthesis thereof 发明人:ANTONUCCI JOSEPH M; STANSBURY JEFFREY W; FOWLER BRUCE O 权利人:US COMMERCE 摘要:A silylated resin suitable for use as an adhesive binder for composites and in sealant and adhesive dental applications is represented by the general formula (I): n in which: n R 1 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n R 2 is the same as R 1 or a different aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group; n M 2 is the same as M 1 or a different functional or nonfunctional group selected from the group consisting of: n n is 1-3; n x is 1-20; and n y is 1-20; n which comprises the reaction product of the exchange reaction of a hydroxylated, aminated, or carboxylated acrylic resin represented by the general formula (II): n in which: n R 4 is an aliphatic, cycloaliphatic, aryl, hydrocarbon, or fluorocarbon group with one or more protic functional groups selected from the group consisting of: n n n OH, N—H, and CO 2 H n n n R 5 is H or CH 3 ; and n R 6 is H or CH 3 ; n with a trialkoxyorganosilane or triacyloxyorganosilane represented by the general formula (III): n in which: n R 7 , R 8 , and R 9 each is: n R 10 is an aliphatic, or aryl group which can optionally be substituted with a group from the group of an acrylic group, a methacrylic group, an epoxy group, and a substituted amino, hydroxyl, or carboxylic acid group such as an ester or an amide.