CAS: 17692-31-8; 3-(4-Phenylpiperazin-1-yl)Propane-1,2-Diol

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CAS号142730-57-2 (R,S)-3-(4-phen...

在 Sodium Hydroxide体系中,用 水 用作溶剂,化学反应 3.0H,以95%的收率获得羟丙哌嗪
参考文献:苯酚官能化鏻盐催化环氧化物固定 Co2 的催化,动力学和机理见解
标题:苯酚官能化鏻盐催化环氧化物固定 Co2 的催化,动力学和机理见解
摘要:研究了一系列羟基官能化鏻盐作为双功能催化剂,用于在温和无溶剂条件下将co 2与环氧化物转化.在苯酚基碘化鏻存在下,反应通过相对于底物的一级反应动力学进行.值得注意的是,与脂肪族类似物相比,苯酚基催化剂没有表现出产物抑制.研究了反应速率的温度依赖性,并根据阿伦尼乌斯图确定了模型反应的活化能(e A =39.6 Kj Mol-1).还评估了底物范围.在优化的反应条件下,20个末端环氧化物在室温下转化为相应的环状碳酸酯,分离收率高达99%.该反应易于扩展,可在高达 50 G 底物的规模上进行.此外,该方法还应用于以环氧氯丙烷和苯基哌嗪为原料合成镇咳药氟哌嗪.此外,还进行了 Dft 计算,以合理化苯酚基碘化鏻催化剂的机理和高效率.计算证实了环氧化物通过碘化物盐的氢键活化,从而促进了开环步骤.值得注意的是,关于该步骤的有效吉布斯能垒对于溴化物是97 Kj Mol-1,对于碘化物盐是72 Kj Mol
Doi:10.1002/cssc.202002267

专利信息

专利号:UA-73790-C2
优先权日:2000-07-28
标 题:2,2-DISPLACED 1,3-DIOXOLANES, METHOD FOR PRODUCING AND APPLICATION AS INTERMEDIATE PRODUCTS FOR SYNTHESIS OF APPROPRIATE (S) -ENANTHIOMERS AND (-) 3- (4-PHENYL-1-PIPERAZYNYLINYLENE-1)

专利号:US-10584156-B2
优先权日:2015-03-13
标 题:Insulin analogues with a glucose-regulated conformational switch
发明人：WEISS MICHAEL
权利人:UNIV CASE WESTERN RESERVE
摘要:A two-chain insulin analogue contains an A chain modified by (i) a monomeric glucose-binding element at or near its N terminus and (ii) a B chain modified by at or near its C terminus by an element that reversibly binds to the monomeric glucose-binding element such that this linkage is displaceable by glucose. The monomeric glucose-binding element may be phenylboronic acid derivative (optionally halogenated). The B chain may be modified by a diol-containing element derived from a monosaccharide, disaccharide or oligosaccharide, a non-saccharide diol-containing moiety or a α-hydroxycarboxylate-containing moiety. The analogue can be manufactured by trypsin-mediated semi-synthesis. Formulations can be at strengths U-10 to U-1000 in soluble solutions at pH 7.0-8.0 with or without zinc ions at a molar ratio of 0.0-3.0 ions per insulin analogue monomer. A patient with diabetes mellitus may be treated with subcutaneous, intraperitoneal, or oral administration of a physiologically effective amount of the insulin analogue.

专利号:PL-206308-B1
优先权日:2000-07-28
标题 :2,2-disubstituted 1,3-dioxolanes, the method of their preparation, the method of their optical separation and their application and the method of levodropropizine synthesis