CAS: 164162-36-1; 2-((Tert-Butyldimethylsilyl)Oxy)Ethyl Trifluoromethanesulfonate
该化合物是一个化学化合物,具有独特的功能组和结构特征,含有一种三丁二甲基硅酸基,可增强有机溶剂的稳定性和溶性,使其在各种合成应用中有用.三氟甲烷泡沫的出现表明它是一个强大的电球,经常被用作核生殖替代反应中的遗留组.这种化合物通常用于有机合成,特别是形成醚和其他衍生物,因为它能促进酒精的活化.其再活性特征受三氟乙烷硫酸组的电饱和性影响,可增强相邻功能组的电益性.此外,三丁二甲基硫酸组可以作为酒精的防护组,在多步骤合成中进行选择性反应.
- 英文名称2-((Tert-Butyldimethylsilyl)Oxy)Ethyl Trifluoromethanesulfonate
- 中文名称2-((叔丁基二甲基甲硅烷基)氧基)乙基三氟甲磺酸酯
- 其它别名2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate; 2-(tert-butyldiMethylsilyloxy)ethyl trifluoroMethanesulfonate; 1,1,1-Trifluoromethanesulfonic acid 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl ester; Trifluoromethanesulfonic acid 2-[[(tert-butyl)dimethylsilyl]oxy]ethyl ester; 2-(t-ButyldiMethylsilyl)oxyethyl triflate
- CAS编号164162-36-1
- MFCD编号:MFCD22572946
- FDA UNII编号:PNY84T2MCF
- 分子式:C9H19F3O4SSi分子量:308.39
- 产品CID: 833964
- 产品分类有机原料→分子砌块→脂肪链类化合物
相似化合物
18928-34-2 88016-31-3 1392400-30-4MSDS等安全信息
上下游产品
CAS号358-23-6 三氟甲磺酸酐 | CAS号102229-10-7 叔丁基二甲基硅氧基乙醇 | CAS号1493-13-6 三氟甲烷磺酸合成工艺路线路线简述
海关参考信息
- 2905310000-1,2-乙二醇
2904100000-仅含磺基的衍生物及其盐和乙酯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9938297-B2
优先权日:2014-08-04
标 题:Process for the synthesis of everolimus and intermediates thereof
发明人：RAO DHARMARAJ RAMACHANDRA; MALHOTRA GEENA; PULLELA VENKATA SRINIVAS; ACHARYA VINOD PARAMESHWARAN
权利人:CIPLA LTD; CIPIA LTD
摘要:The present invention relates to a novel process for the synthesis of everolimus of formula (I): n nand intermediates thereof.
专利号:US-10308665-B2
优先权日:2015-06-23
标题 :Method for the synthesis of rapamycin derivatives
发明人：ZABUDKIN OLEKSANDR; SCHICKANEDER CHRISTIAN; MATVIIENKO IAROSLAV; SYPCHENKO VOLODYMYR
权利人:SYNBIAS PHARMA AG
摘要:The present invention relates to a method for the production of a rapamycin derivative of formula (I), the method comprising the preparation of a 2-(tri-substituted silyl)oxyethyl triflate by reacting ethylene oxide and a tri-substituted silyl triflate, reaction of the resulting 2-(tri-substituted silyl)oxyethyl triflate with rapamycin in the presence of a molar excess of organic base, and deprotection to obtain the rapamycin derivative of compound (I).
专利号:US-6277983-B1
优先权日:2000-09-27
标 题:Regioselective synthesis of rapamycin derivatives
发明人：SHAW CHIA-CHENG; SELLSTEDT JOHN; NOURELDIN RAZZAK; CHEAL GLORIA K; FORTIER GENEVIEVE
权利人:AMERICAN HOME PROD
摘要:This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
专利号:EP-1216251-B1
优先权日:1999-09-29
标题 :Regioselective synthesis of rapamycin derivatives
发明人：SHAW CHIA-CHENG; SELLSTEDT JOHN HAMILTON; NOURELDIN RAZZAK; CHEAL GLORIA KAREN; FORTIER GENEVIEVE
权利人:WYETH CORP
摘要:This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
专利号:US-2019010168-A1
优先权日:2015-06-23
标题:Method for the synthesis of rapamycin derivatives
专利号:US-9079921-B2
优先权日:2010-11-19
标题 :Processes for preparation of Everolimus and intermediates thereof
发明人：VENKATA SRINIVAS PULLELA; EKAMBARAM GANESH; KOTHAKONDA KIRAN KUMAR; PRASAD ANEGONDI SREENIVASA
权利人:VENKATA SRINIVAS PULLELA; EKAMBARAM GANESH; KOTHAKONDA KIRAN KUMAR; PRASAD ANEGONDI SREENIVASA; BIOCON LTD
摘要:The present disclosure discloses processes of Everolimus and intermediates: reacting Sirolimus (Rapamycin) under solvent free conditions with appropriate side chain implying portion wise additions, one pot conversion, and resin mediated synthesis.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2004).
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