CAS: 16297-07-7; 2,3,5,6-Tetrafluoroisonicotinonitrile

相似化合物

16297-09-9 2875-10-7 1210041-67-0

上下游产品

CAS号16297-06-6 2,3,5,6-四氯异烟腈 | CAS号773837-37-9 sodium cyanide | CAS号700-16-3 五氟吡啶 | CAS号100-48-1 4-氰基吡啶 | CAS号266312-20-3 2,3,5-三氟吡啶-4-甲醛 | CAS号16297-09-9 2,3,5,6-Tetrafl...

📜4-氰基吡啶置于potassium Fluoride,五氯化磷体系中,化学反应 20.0H,反应生成2,3,5,6-四氟吡啶-4-腈
参考文献:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
标题:Synthesis Of Some Fluorine-Containing Pyridinealdoximes Of Potential Use For The Treatment Of Organophosphorus Nerve-Agent Poisoning
摘要:Fluoroheterocyclic Aldoximes Were Screened As Therapeutic Agents For The Treatment Of Anticholinesterase Poisoning. 2-Fluoropyridine-3-And-6-Aldoxime,And 3-Fluoropyridine-2-And-4-Aldoxime,Were Synthesised. Attempts To Obtain 3,5,6-Trifluoropyridine-2,4-Bis(Aldoxime) And-2-Aldoxime,However,Proved Unsuccessful. Pentafluorobenzaldoxime Was Prepared By Oximation Of Pentafluorobenzaldehyde. Acid Dissociation Constants (Pk(A)) And Second-Order Rate Constants (K(Ox)-) Of The Fluorinated Pyridinealdoximes Towards Satin Were Measured. 2,3,5,6-Tetrafluoropyridine-4-Aldoxime Had The Best Profile: Its K(Ox)-Approached That Of The Therapeutic Oxime P2S (310 Vs. 120 L Mol(-1) Min(-1)),But Its Higher Pk(A) (9.1 Vs. 7.8) Fell Short Of The Target Figure Of 8 Required For Reactivation Of Inhibited Acetylcholinesterase In Vivo. N-Alkylation Of The Fluorinated Pyridine-Aldoximes May Reduce Their Pk(A) Nearer To 8 And Enhance Their Therapeutic Potential. Crown Copyright (C) 2011 Published By Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Jfluchem.2011.05.028

专利信息

专利号:CN-104387369-B
优先权日:2014-10-28
标题:Synthesis method and application of thermally activated delayed fluorescent material