CAS: 16096-13-2; 2-Isopropoxypyridine

相似化合物

83766-88-5 903886-71-5 1017577-23-9

上下游产品

2-chloropyridine sodium isopropylate isopropyl alcohol 2-hydroxypyridin2-Pyridone propene 1-isopropylpyridin-2(1H)-one

📜2-氨基吡啶,原甲酸三异丙酯置于亚硝酸特丁酯体系中,化学反应 1.0H,以81%的收率获得2-异丙氧基吡啶
参考文献:邻位烷氧基取代的吡啶类化合物的制备方法
标题:邻位烷氧基取代的吡啶类化合物的制备方法
摘要:本发明提供一种邻位烷氧基取代的吡啶类化合物的制备方法,包括:使邻位氨基取代的吡啶类化合物与原甲酸酯类化合物在亚硝酸酯类化合物的存在下反应,生成所述邻位烷氧基取代的吡啶类化合物.本发明具有效率高,成本低,环保等优点.

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:EP-2300484-B1
优先权日:2008-05-05
标题:Novel class of spiro piperidines for the treatment of neurodegenerative diseases
发明人：BRODNEY MICHAEL AARON; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.