CAS: 14999-43-0; Glucosamine (Hemisulfate)

专利信息

专利号:US-2014349962-A1
优先权日:2013-05-24
标 题 :Rapid two-step synthesis of anti-coagulants
发明人：ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAB
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides methods for the production of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, compounds thus obtained and compositions comprising same. This invention also provides applications of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, and compositions comprising same, for use in controlling coagulation and treating thrombosis.

专利号:US-8450297-B2
优先权日:2004-08-16
标 题:Rapid two-step synthesis of anti-coagulants
发明人：ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAN
权利人:ROSENBERG ROBERT D; BALAGURUNATHAN KUBERAN; MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides methods for the production of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, compounds thus obtained and compositions comprising same. This invention also provides applications of N-deacetylate N-sulfate derivatives of non-sulfated N-acetyl heparosan (HS) polysaccharides, and compositions comprising same, for use in controlling coagulation and treating thrombosis.

专利号:WO-0053189-A1
优先权日:1999-03-10
标 题:Inhibitors of calcium influx factor synthesis and/or action and uses thereof
发明人：MARCHASE RICHARD B; BLALOCK JAMES EDWIN; BOUNELIS PAM; CSUTORA PETER; HUNTON DACIA; SU ZHENGCHANG
权利人:UAB RESEARCH FOUNDATION
摘要:The present invention is directed to inhibitors of Calcium Influx Factor (CIF) synthesis and/or action and their potential applications as immunosuppressants, Th1/Th2 effectors, or therapeutic agents for cardiac hypertrophy. Glucosamine and metabolites are examples of such inhibitors.

专利号:US-8183409-B2
优先权日:2004-05-06
标题:High yield and rapid synthesis methods for producing metallo-organic salts
发明人：CHRISTGAU STEPHAN; ANDERSEN JENS E T
权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

专利号:US-11993606-B2
优先权日:2015-10-16
标题:Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
发明人：MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; PANGAN AILEEN L; SONG IN-HO; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

专利号:US-11976077-B2
优先权日:2015-10-16
标 题 :Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms therof
发明人：PANGAN AILEEN L; TEIXEIRA HENRIQUE D; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.